IndraLab

Statements

CYLD decreases the amount of SCIN. 3 / 3
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"As our preliminary data shows that CYLD knockdown is able to upregulate IL-4 and Scinderin expression in human Treg cells (data not shown), this indicates that CYLD may play an important role in Treg cells in humans."
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"In line with this notion, Scinderin expression was upregulated by the CYLD deficiency, leading to an enhancement of the MAPK signaling pathway that induces IL-4 expression."
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"Collectively, the data suggest that CYLD deficiency induces Scinderin expression, which is critical in regulating IL-4 production in Treg cells."
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