IndraLab

Statements

USP10 binds DnaK. 9 / 9
| 2 7
sparser
"DnaK DnaK binds to USP10 and affects p53-dependent anticancer functions."
35627217
reach
"We demonstrate that mycoplasma DnaK interacts with and reduces the activities of human proteins involved in critical cellular pathways, including DNA-PK and PARP1, which are required for efficient DNA repair, and binds to USP10 (a key p53 regulator), impairing p53 dependent anticancer functions."
30509983
sparser
"At the same time, the interaction of DnaK with USP10 reduces p53 activity, preventing its anticancer effectiveness."
30509983
sparser
"Taken together, our results indicate that DnaK binding to USP10 prevents its deubiquitinating activity, thus reducing p53 stability and its anticancer functions and the cellular response to some anticancer drugs."
30509983
sparser
"USP10 deubiquitinates p53, regulating the DNA-damage response; DnaK interacts with USP10, inhibiting its deubiquitination activity [34] ."
35627217
sparser
"We demonstrated that this mycoplasma’s DnaK binds to human USP10 (ubiquitin carboxyl-terminal hydrolase 10, a regulator of p53 stability), reducing p53 stability and anti-cancer functions, potentially increasing the likelihood of DNA mutations and consequent malignant transformation [ xref ]."
32075244
sparser
"Mycoplasma DnaK Binds USP10 and Impairs p53-Dependent Functions."
30509983
sparser
"We first confirmed the interaction between DnaK and USP10 by immunoprecipitation studies ( xref )."
30509983
reach
"We demonstrated that this mycoplasma’s DnaK binds to human USP10 (ubiquitin carboxyl-terminal hydrolase 10, a regulator of p53 stability), reducing p53 stability and anti-cancer functions, potentially increasing the likelihood of DNA mutations and consequent malignant transformation [107]."
32075244