IndraLab

Statements

USP37 is phosphorylated. 34 / 34
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"Inactivation of CDK2 in mitosis results in loss of USP37 phosphorylation."
21596315
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"These results suggested that CDK1-mediated phosphorylation of USP37 is crucial for its deubiquitinase activity on SND1."
40486858
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"Therefore USP37 phosphorylation correlated with its cell cycle-specific DUB activity."
21596315
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"Next, we studied the function of CDK1-mediated USP37 phosphorylation in SND1-driven malignant processes."
40486858
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"Finally, recombinant CDK2/cyclin A phosphorylated wild-type USP37, but neither USP37-S 628 A nor USP37-S 628 D, in an in vitro kinase assay ( Figure 7 H)."
21596315
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"Collectively, these data identify CDK2 as the kinase responsible for phosphorylating and activating USP37 during G1/S. We show that USP37 is a DUB that associates with and antagonizes APC CDH1 follow[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
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"Therefore USP37 phosphorylation, like RB, is a marker for the G1/S transition."
21596315
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"These results indicated that CDK1-mediated phosphorylation of USP37 is essential for its effect on the SND1-dependent malignant phenotype in CRC progression."
40486858
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"We think that USP37, which is itself an APC CDH1 substrate ( Figure 5 ), is stable during S and G2 for two reasons: (1) phosphorylated USP37 deubiquitinates itself, and (2) CDH1 is phosphorylated by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21596315
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"Our findings demonstrate that CDK1-mediated phosphorylation of USP37 is indispensable for its deubiquitinase activity towards SND1- and SND1-driven processes, such as cell proliferation and cancer metastasis ( xref J)."
40486858
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"CDK1/2 inhibitors, but not CDK4/6 inhibitors, inhibited USP37 phosphorylation ( xref )."
37955924
rlimsp
"Plk1-mediated phosphorylation of USP37 plays an important role in its recognition by SCF-β-TrCP [7]."
25347529
rlimsp
"We observed that just as CDC6, the levels of USP37 protein and phosphorylated USP37 decreased in the presence of CDK2 inhibitor ( )."
25347529
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"Another possibility is that phosphorylated USP37 recruits cofactors that increase its DUB activity."
21596315
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"As illustrated in xref I, phosphorylation of USP37 (USP37 Thr631A) nearly completely abolished the phosphorylation of USP37."
40486858
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"Subsequently, we conducted in vitro kinase assays in which recombinant CDK1/cyclin B phosphorylated USP37 WT but not USP37 Thr631A ( xref J)."
40486858
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"We found this interesting because USP37 has been implicated in cell proliferation and transformation [ 6, 7 ] as well as in cell-cycle regulation, where during the G1/S transition, CDK2 phosphorylates[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26299517
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"Considering that both USP37 and CDK1 enhanced the stability of SND1 and that CDK1 phosphorylated USP37, we hypothesized that the regulation of SND1 by CDK1 might be mediated by the activation of USP37."
40486858
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"In the presence of the CDK1 inhibitor RO-3306, recombinant CDK1/cyclin B-mediated phosphorylation of USP37 WT was also nearly undetectable."
40486858
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"Next, we investigated whether USP37 phosphorylation affects its ability to remove ubiquitination of SAMHD1."
39655951
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"As shown in xref , the S628A mutant of USP37 markedly decreased phospho-CDK substrate signaling, suggesting that S628 is a major site for CDK1/2 mediation of USP37 phosphorylation."
37955924
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"However, USP37 phosphorylation did not affect its binding to ERK1/2 ( xref )."
37955924
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"Therefore, the phosphorylation of USP37 does not affect its deubiquitination activity toward SAMHD1."
39655951
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"These findings suggest that the CDK2-mediated phosphorylation of USP37 exerted a vital function in regulating USP37 DUB activity and the USP37-mediated deubiquitination and stabilization of ERK1/2."
37955924
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"CDK1 binds and phosphorylates USP37."
40486858
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"Furthermore, phosphorylation of USP37 is a cell cycle-dependent event."
34177595
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"Meanwhile, USP37 is phosphorylated and activated by CDK2, promoting the removal of polyubiquitin chains from ERK1/2 and resulting in the stabilization of ERK1/2."
37955924
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"We studied whether the upregulation and malignant progression of SND1 in CRC mediated by CDK1 is mediated by the phosphorylation of USP37."
40486858
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"Moreover, our study highlights a novel regulatory mechanism involving CDK1-mediated phosphorylation of USP37, which stabilizes SND1 and promotes CRC progression."
40486858
rlimsp
"Further, inhibition of CDK2 activity in HBx expressing cells, resulted in a decrease of not only phosphorylated USP37 but also total USP37 protein levels."
25347529
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"Subsequent phosphorylation of USP37 by either CDK2/cyclin E or CDK2/cyclin A triggers its full DUB activity."
21596315
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"CDK2 regulates ERK1/2 stability by phosphorylating and activating USP37."
37955924
sparser
"A detailed structural analysis of phosphorylated USP37 may be required to reveal this mechanism."
34177595
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"Subsequently, we studied whether the phosphorylation of USP37 mediated by CDK1 affects the ubiquitination level of SND1."
40486858