IndraLab

Statements

FOXH1 inhibits KCNH2. 6 / 6
| 6
sparser
"Interestingly, when residue Ile470 is mutated to a tyrosine in Shaker , an inverted inactivating phenotype was observed, reminiscent of the fast inactivation of hERG channels xref ."
20613845
sparser
"Due to fast inactivation of hERG1 channels, strong depolarizations elicited rather small outward currents, whereas subsequent repolarization to −120 mV led to large slowly deactivating inward tail currents ( xref )."
20097192
sparser
"In the absence of drug, the I - V relationship exhibited the characteristic bell-shaped curve increasing from −40 to 0 mV, and owing to the fast C-type inactivation of HERG channels, it decreased with further depolarization."
24069049
sparser
"Although lowering K + o accelerates the fast inactivation of hERG channels ( xref , xref ; xref ), and this effect was initially thought to be responsible for the effect of K + o on the hERG current magnitude ( xref ), a quantitative analysis by xref suggested that the changed fast-inactivation rate is not responsible for the altered current amplitude."
16769794
sparser
"The structural analysis indicates that KCNQ1 Val162Met is oriented away from functionally important regions, while Ser55Leu is positioned at domains critical for KCNH2 fast inactivation."
29330128
sparser
"Fast inactivation of HERG and the resulting rectification are partly responsible for the prolonged plateau phase typical of ventricular action potentials."
8740374