IndraLab

Statements

IL10 increases the amount of USP18. 4 / 5
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"In the present study, treatment of hepatic cells with LPS and TNF-alpha, but not IL-6 or IL-10, led to upregulated USP18 expression in hepatocytes."
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"USP18 mRNA expression was induced by TNF-alpha and LPS but not by IL-6 or IL-10 (XREF_FIG)."
27009955
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"We examined the ability of inflammatory stimuli, including tumor necrosis factor alpha (TNF-alpha), lipopolysaccharide (LPS), interleukin-6 (IL-6) and IL-10 to upregulate hepatocyte USP18 expression and blunt the IFN-alpha response."
27009955
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"Treatment of Huh7.5 cells and primary murine hepatocytes with LPS and TNF-alpha, but not IL-6 or IL-10, led to upregulated USP18 expression and induced an IFN-alpha refractory state, which was reversed by USP18 knockdown."
27009955