IndraLab

"Coronaviruses (CoVs) are a large family of RNA viruses that cause respiratory tract infections, ranging from the mild common cold to serious diseases such as severe acute respiratory syndrome (SARS), middle east www.advancedsciencenews.com www.advancedscience.com Inhibiting TLR/NF-B signaling [ 100] TRIF USP19 K27 Inhibiting TLR3/4-mediated signaling [98] TRAF6 A20 K63 Terminating TLR-induced activity [91] USP4 K63 Preventing NF-B and AP1 activation, inhibiting TLR/IL-1R signaling [ 102] USP 10 K63 Interacting with TANK and MCPIP1, terminating NF-B activation in response to TLR [ 104] MYSM1 K63 Terminating TLR-mediated antiviral responses [ 101] OTUD1 K48 Inhibiting IFN production [ 175] OTUB1/2 K63 Inhibiting antiviral responses [ 172] TRAF3 MYSM1 K63 Terminating TLR-mediated antiviral responses [ 101] UCHL1 K63 Inhibiting IFN production [ 103] OTUD1 K48 Inhibiting IFN production [ 175] OTUB1/2 K63 Inhibiting antiviral responses [ 172] RIP1 (also known as RIPK1) A20 K63 Inhibiting NF-B signaling [92] CYLD K63 Inhibiting NF-B signaling [95] A20 K48 Inducing A20 degradation with E3 ligase activity, inhibiting NF-B signaling [92] NEMO A20 N/A Binding to ubiquitinated NEMO, blocking IKK phosphorylation, inhibiting NF-B activation [93] CYLD M1 Inhibiting NF-B signaling [97] USP10 M1 Interacting with NEMO via MCPIP1, inhibiting the genotoxic NF-B signaling [40] TAK1 USP18 K63 Inhibiting TLR/NF-B signaling [ 116] RIG-I USP5 K48 Interacting with STUB1, mediating RIG-I degradation, enhancing VSV replication [ 174] CYLD K63 Inhibiting IFN production [ 162] USP3 K63 Inhibiting antiviral responses upon viral infection [ 164] USP21 K63 Inhibiting antiviral responses [ 165] USP14 K63 Inhibiting antiviral responses [ 167] USP27X K63 Inhibiting antiviral responses [ 168] USP15 K63 Inhibiting antiviral responses [ 169] MAVS YOD1 K63 Inhibiting IRF3 and p65 activation, IFN-production, inhibiting antiviral responses [ 170] OTUD1 K48 Inhibiting IFN production [ 175] OTUD3 K63 Inhibiting antiviral responses [ 171] STING USP49 K63 Inhibiting antiviral responses after HSV-1 infection [ 217] USP21 K63 Inhibiting type I interferon production induced by DNA virus [ 219] USP13 K27/33 Impairing the recruitment of TBK1 to STING, inhibiting antiviral responses [ 218] USP21 K27 Inhibiting type I interferon production induced by DNA virus [ 219] USP22 K27 Interacting with USP13 [ 174] TBK1 A20 K63 Inhibiting antiviral responses with TAX1BP1 [ 232] USP2b K63 inhibiting TBK1 kinase activity, terminating TBK1 activation, inhibiting IFN-signaling [ 233] USP7 K48 Interacting with and stabilizing TRIM27, inhibiting antiviral type I IFN signaling [ 235] USP38 K33 Interacting with TBK1 via NLRP4, allowing DTX4-and TRIP-mediated K48-linked polyubiquitination, promoting TBK1 degradation, inhibiting IFN-I signaling [ 236] IRF3 OTUD1 K63 Inhibiting IRF3 nuclear translocation and its transcriptional activity [ 244] K6 Disassociation of IRF3 from the promoter region of target genes, inhibiting type I IFN induction [ 245] Signaling activation TRAF3 USP25 K48 Preventing TRAF3 degradation following virus infection, facilitating antiviral responses [ 117, 180] OTUD7B K48 Inhibiting TRAF3 proteolysis, preventing aberrant non-canonical NF-B activation [ 118] RIG-I USP15 K63 Removing K48-linked polyubiquitin chains on TRIM25, promoting IFN-I expression [ 181] USP4 K48 Stabilizing RIG-I, prolonging IFN induction [ 177] USP17 K48 Stabilizing RIG-I, facilitating antiviral responses [ 176] (Continued) Adv."