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Nitric oxide activates KCNMA1. 20 / 20
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"Because L-NAME prevented hyperpolarization to SP in SMCs ( Figure 4 ) , we suggest that KCa channels ( likely BK ) on SMCs are activated by endothelium-derived NO to mediate hyperpolarization , which can occur through cGMP - and PKG-dependent phosphorylation.37 ,39 Alternatively , direct activation of BK channels by NO has been reported in vascular smooth muscle independent of guanylate cyclase signaling.40 Because SK and IK channels can regulate NO synthesis in ECs ,30,41 it is possible KCa inhibition in ECs prevents SMC hyperpolarization by limiting NO production ."