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PKC phosphorylates KCNQ1. 10 / 10
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"In addition, it has been postulated that by directly phosphorylating four putative C-terminals PKC phosphorylation sites of KCNQ1, PKC increases the current amplitude [45]."
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"Our results suggest that the regulation of the KvLQT1 and MinK potassium channel via beta (3)-AR is substantially mediated by PKC phosphorylation of the KvLQT1 protein at its four C-terminal PKC phosphorylation sites."
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"Experiments in which the putative C-terminal PKC phosphorylation sites in the KvLQT1 protein were destroyed by site directed mutagenesis reduced the isoproterenol induced current to 27 +/-3,5% compared to control."
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"There are nine putative PKC phosphorylation sites (S/T-X-K/R) in KCNQ1, and five of the nine PKC phosphorylation sites are located on the C-terminus (T391, S409, S464, T513 and S577) ( Fig. 1 )."
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"Alternatively, because KCNQ1 has four more PKC phosphorylation sites outside the C-terminus, PKC may directly phosphorylate KCNQ1 to lead to its internalization."
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"Alternatively, because KCNQ1 has four more PKC phosphorylation sites outside the C-terminus, PKC may directly phosphorylate KCNQ1 to lead to its internalization."
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"Our results suggest that the regulation of the KvLQT1/MinK potassium channel via beta(3)-AR is substantially mediated by PKC phosphorylation of the KvLQT1 protein at its four C-terminal PKC phosphorylation sites."
12879210
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"Therefore, we propose that 17β-estradiol decreases basal and enterotoxin-induced Cl − secretion by activating PKCδ, which phosphorylates basolateral KCNQ1 channels to reduce K + recycling and thereby [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Human beta (3)-adrenoreceptors couple to KvLQT1 and MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein."
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"Dexamethasone rapidly induces a PKCδ phosphorylation of the KCNQ1:KCNE3 channel complex resulting in its dissociation and collapse of the channel conductance."
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