IndraLab

Statements


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sparser
"Compared to their respective counterparts, advanced stage, PNI, and LVI associated with a significantly increased risk of locoregional recurrence."

sparser
"MAC (hazard ratio [HR] 1.85, 95% confidence interval [CI], 1.15-2.98), PNI (HR 3.23, 95% CI, 1.85-5.72) and LVI (HR 2.04, 95% CI, 1.02-4.08) were independent prognosis factors and were associated with worse DFS."

sparser
"Using Kaplan-Meier analysis for overall survival rate, we have found that both LVI and PNI were associated with lower survival rates ( P < 0.01)."

sparser
"As LVI and PNI are associated with increased rates of distant metastasis xref , including these two predictive factors may improve the sensitivity and specificity of our nomogram."

sparser
"Further, the median number of resected LN in all groups were greater than the recommended number of 16 nodes. xref However, given the strong association of LVI and PNI with positive nodal disease, for patients in whom inadequate LN harvest is achieved, the presence of LVI and PNI in the absence of diagnosed pathologic nodal disease, should be considered as an indicator for potentially more advanced disease than was possible to identify pathologically."

sparser
"Using Kaplan-Meier analysis for overall survival rate, we have found that both LVI and PNI were associated with lower overall survival rates as well as disease free survival rates ( P < 0.01)."

sparser
"In our study, high c-Myc nuclear expression of the overall tumor was significantly associated with sarcomatoid variant, PNI, LVI, lymph node metastasis, distant metastasis and advanced stage grouping, while there was no significant association with gender, age, tumor diameter, divergent differentiation, bilharziasis, necrosis, pathological tumor stage (pT) and recurrence."

sparser
"To identify genes that differentiate PNI from LVI, we performed a differential expression analysis between PNI + LVI − and LVI + PNI − patients, unveiling 228 and 1755 genes uniquely associated with PNI and LVI, respectively ( P adj < 0.005) ( xref )."

sparser
"Identification of six genes associated with LVI and PNI."