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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PTEN activates mutated TP53. 2 / 2

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"In PBK and TOPK overexpressing GC cells, knockdown of PBK and TOPK inhibited the cell proliferation through the p53 activation in a TP53 mutation dependent manner and inhibited the migration and invasion through the PTEN upregulation in a TP53 mutation independent manner."

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"We confirmed the interactions of IPMK and PTEN with stress-induced p53 and mutant p53 by co-IP (Fig. 4f, g and Extended Data Fig. 3i)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...