IndraLab

Statements

KCNMA1 activates JNK. 10 / 10
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"The fact that purified SLO could also activate JNK suggests that SLO is both necessary and sufficient to trigger activation."
26838722
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"Of these, only JNK was activated specifically in response to pore formation by SLO."
26838722
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"While SLO is required to activate both during infection, purified SLO activates JNK but not PARP-1."
26838722
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"While purified SLO and other pore forming toxins have been shown to activate several classes of MAPK, only JNK was specifically activated by SLO in the context of S.pyogenes infection."
26838722
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"Chandrasekaran and colleagues observed increased GAS toxicity to epithelial cells in the presence of enzymatically inactive NADase compared to strains harboring an NADase deletion and further suggested that inactive NADase could contribute to programmed cellular necrosis through the JNK pathway, a process that can also be mediated by SLO."
28900022
sparser
"While purified SLO and other pore-forming toxins have been shown to activate several classes of MAPK ( xref , xref , xref ), only JNK was specifically activated by SLO in the context of S. pyogenes infection."
26838722
sparser
"While SLO is required to activate both during infection, purified SLO activates JNK but not PARP-1 ( xref )."
26838722
reach
"SLO was both necessary and sufficient to activate JNK, as exposure of HeLa cells to a range of concentrations of purified SLO activated JNK in a concentration dependent manner (XREF_FIG)."
26838722
sparser
"The fact that purified SLO could also activate JNK suggests that SLO is both necessary and sufficient to trigger activation."
26838722
sparser
"SLO was both necessary and sufficient to activate JNK, as exposure of HeLa cells to a range of concentrations of purified SLO activated JNK in a concentration-dependent manner ( xref )."
26838722