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KCNQ2 activates potassium(1+). 7 / 7
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"Heteromeric KCNQ2 and KCNQ3 channels have been proposed to underlie the neuronalM-current, a subthreshold, non-inactivating potassium current which is an important determinant of membrane excitability[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Co-expression of KCNQ2 and KCNQ3 leads to a large increase of the potassium current, suggesting that the proteins interact as heterodimers."
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"It is suggested that KCNQ2 and KCNQ3 contribute to the formation of the native M-current, a slowly activating and deactivating potassium conductance."
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"[7] KCNQ2 gene causes dysfunction of potassium ion channels, and because they co-localise with sodium channels, it leads to increased excitatory neurotransmission."
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"Expression of KCNQ2 in frog (Xenopus laevis) oocytes led to potassium selective currents that activated slowly with depolarization."
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"KCNQ2 and KCNQ3 K+ channel subunits underlie the muscarinic regulated K+ current (I (KM)), a widespread regulator of neuronal excitability."
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"KCNQ2 channel subunits form part of the M-current and underlie one of the major potassium currents throughout the human nervous system, regulating resting membrane potentials, shaping action potentials, and impeding repetitive neuronal firing."
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