IndraLab

Statements

ZUP1 activates viral process. 2 / 2
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"For CCHFV, it was recently shown that the stable occupancy of the CCHFV-encoded DUB with a Ub variant, blocking OTU DUB activity, blocked viral infection in addition to enhancing host antiviral responses [205]."
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"Specifically, PLPs use their DUB activity to interfere with the proteins that mediate the intracellular sensing and signaling of viral infection, therefore leading to a dysregulation of the immune pathways, such as the IRF3 and NF-kB pathways, that in turn, results in a decrease in the antiviral response."
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