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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ZUP1 activates viral process. 2 / 2

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"For CCHFV, it was recently shown that the stable occupancy of the CCHFV-encoded DUB with a Ub variant, blocking OTU DUB activity, blocked viral infection in addition to enhancing host antiviral responses [205]."

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"Specifically, PLPs use their DUB activity to interfere with the proteins that mediate the intracellular sensing and signaling of viral infection, therefore leading to a dysregulation of the immune pathways, such as the IRF3 and NF-kB pathways, that in turn, results in a decrease in the antiviral response."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...