IndraLab

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Cyclin_E phosphorylates NPM1. 13 / 13
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"We show that centriole duplication is blocked when nuclei were preincubated with the anti-NPM and B23 antibody that prevents phosphorylation of NPM and B23 by CDK2 and cyclin E."
12429912
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"In addition to NPM’s phosphorylation by cyclin E–cdk2, its nuclear export by the Ran–Crm1 complex has also been implicated in NPM’s induction of centrosome duplication."
19561638
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"Cdk2-cyclin E phosphorylates nucleophosmin on isolated centrosomes , causing it to be dissociated from the centrosomes."
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"Phosphorylation of nucleophosmin by Cdk2 and cyclin E results in nucleophosmin 's removal from the centrosome, coinciding with initiation of procentriole formation."
19277494
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"Moreover, while cyclin E dependent kinase activity in wild-type cells could be significantly induced by serum mediated growth stimulation, further activation in E2F3 -/- cells was minimal.Considering [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12726860
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"The cdk2 and cyclin E complex phosphorylates nucleophosmin and B23, which associates specifically with unduplicated centrosomes and may be involved in initiating centrosome duplication [36]."
12106655
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"At late G 1 phase, NPM is phosphorylated by cyclin E-Cdk2, phosphorylation which induces NPM release from the centrosomes and the initiation of centrosomal duplication. xref We found that AKAP350CTD expression induced an increase in Cdk2 specific phosphorylation of NPM, indicating that AKAP350 enables Cdk2 centrosomal activity at the G 1 /S transition."
24475373
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"GST-NPM and B23 preincubated with either anti-gag (lane 2) or anti-myc (lane 3) antibody was phosphorylated by CDK2 and cyclin E at similar levels with the control with no antibody (lane 1)."
11051553
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"In transactivation activity dependent mechanism, p21 expression plays a key role in synchronizing DNA replication and centrosome duplication by inhibiting Cdk2 and Cyclin E activity which phosphorylates Nucleophosmin and NPM1 at centrosomes to promote its dissociation from the centrosomes to allow initiation of centrosome duplication."
27933271
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"Considering the established link between cyclin E-dependent phosphorylation of nucleophosmin and centrosome duplication, our results raised the possibility that deregulated cyclin E activity in E2F3-d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12726860
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"As phosphorylation of human NPM by cyclin E–cdk2 was reported to be essential for the initiation of centrosome duplication in late G 1 ( xref ), we considered that ARF might inhibit NPM phosphorylation in addition to retaining it in the nucleolus to arrest cell growth before S-phase entry ( xref )."
19561638
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"These results suggest that NPM and B23 phosphorylated by CDK2 and cyclin E dissociates from centrosomes."
11051553
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"The phosphorylation of NPM1 by CDK2 and Cyclin E promotes the release of NPM1 from the centrosome during duplication; this represents an essential step for duplication to occur."
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