IndraLab

Statements

RA190 inhibits UCHL5. 5 / 5
| 5
reach
"RA190 does not affect hRpn13 interaction with Uch37, but rather directly binds and inactivates Uch37."
28598414
reach
"We propose that RA190 deactivation of Uch37 at the proteasome contributes to induction of apoptosis."
28598414
reach
"These findings indicate that RA190 inhibits Uch37 activity and, moreover, that it has a direct effect that is independent of hRpn13."
28598414
reach
"Since Uch37 is expected to disassemble ubiquitin chains at hRpn13 in the proteasome, we hypothesized that RA190 inactivation of Uch37 could impair the disassembly and clearance of ubiquitin chains from the proteasome."
28598414
reach
"These data suggest that RA190 does not block UCH37 DUB activity in cellular microenvironment."
27118409