IndraLab

Statements

IGF1R phosphorylates IRS1 on tyrosine. 16 / 20
| 13 3 4
reach
"IGF-I rapidly stimulated beta-chain IGF-I receptor autophosphorylation, which peaked at a physiological and mitogenic concentration (1.4 nM) and also stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1)."
8756554
reach
"Notably, IGF-1R also phosphorylates tyrosine residues of IRS1 and Shc, creating docking platforms for PI3K and Grb2, which activate the Akt and ERK pathways, respectively [54]."
38326807
reach
"IGF-I-stimulated autophosphorylation of the IGF-IR and tyrosine phosphorylation of IRS-1 and SHC, known substrates in the IGF-IR signal transduction pathway, were studied."
9202243
reach
"Evidence of an EGFR-IRS-1 interaction arises from reports by Fujioka and colleagues [XREF_BIBR, XREF_BIBR], who reported that the phosphorylated NPXY motifs in activated IR and IGF-IR to which IRS molecules bind are also present in the C-terminus region of activated EGFR and were indispensable for EGF induced IRS-1 tyrosine phosphorylation in EGFR transfected CHO cells [XREF_BIBR]."
21939528
reach
"IGF-1R is a tyrosine kinase receptor that is activated by IGFs, the activated IGF-1R not only phosphorylates IRS-1 and SHC to activate the MAPK cascade, which stimulates cell growth and proliferation [XREF_BIBR], but also protects from apoptosis as a result of activation of PI3K-Akt through phosphorylation and subsequent inactivation of BAD [XREF_BIBR]."
24810113
reach
"IGF-1R phosphorylates the insulin receptor substrate-1 (IRS-1) at the tyrosine site, leading to aberrant activation of downstream signaling pathways, such as the PI3K/Akt pathway [ 19–21 ]."
31461670
sparser
"Phosphorylation of various tyrosine residues on IRS-1 by IR or IGF-1R creates docking sites for several SH2 domain-containing proteins, such as growth factor receptor binding protein-2 (Grb2), the p85[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15923229
reach
"Upon binding of IGF-I or IGF-II, IGF-1R, a tyrosine kinase, phosphorylates tyrosine residues on two major substrates, IRS-1 and Shc, which subsequently signal through the Ras and Raf and PI 3-kinase/AKT pathways (7)."
15500006
reach
"Phosphorylation of various tyrosine residues on IRS-1 by IR or IGF-1R creates docking sites for several SH2 domain-containing proteins, such as growth factor receptor binding protein-2 (Grb2), the p85[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15923229
reach
"In immature rat GCs, FSH signals via its G protein coupled receptor to promote the protein kinase A (PKA)-dependent activation of the PI3K pathway by regulating the tyrosine phosphorylation of IRS1 by the IGF 1 R."
27328024
sparser
"Then, IGF-1R phosphorylates IRS1 and Shc on tyrosine residues [ xref ], forming docking sites for PI3K and GRB2, and activating Akt and ERK pathways, respectively [ xref ] ( xref )."
39201539
reach
"When cells are only stimulated by IGF-I, the IGF-IR induces the tyrosine phosphorylation of IRS-1 which recruits docking proteins such as PI 3-kinase and initiates specific IGF downstream signaling pa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22227580
reach
"Downregulation of beta 1 blocks IGF stimulated cell proliferation and transformation of prostate cancer cells, but the effect of beta 1 downregulation on activation of IGF-IR and tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) has never been described."
20333644
sparser
"Notably, IGF-1R also phosphorylates tyrosine residues of IRS1 and Shc, creating docking platforms for PI3K and Grb2, which activate the Akt and ERK pathways, respectively [ xref ]."
38326807
reach
"On ligand stimulation, IGF-IR, a receptor tyrosine kinase, phosphorylates tyrosine residues on two major substrates, IRS-1 and Shc, which subsequently signal through the Ras and mitogen activated protein kinase and phosphatidylinositol 3-kinase/AKT pathways."
16093437
reach
"Insulin like growth factor 1 receptor is an RTK, and phosphorylates multiple tyrosine residues of IRS1 to activate PI3K and its downstream signal pathway including Akt, mTOR, and S6K1."
25483727