IndraLab

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SCN4A activates Ala-Pro. 3 / 3
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"Consequently, in our two cell delivery model, expression of SkM1, but not SCN5A enhanced the dV/dt max of the AP upstroke in myocytes which were electrically coupled with HEK293 cells transfected with either of these Na + channel genes."
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"After demonstrating that SkM1 increases the AP upstroke, we then tested the effect of SkM1 on conduction velocity."
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"Epicardial mapping, programmed electrical stimulation, and microelectrode recordings demonstrated that overexpression of the SkM1 channel increased V max of the AP, improved conduction velocity, and suppressed VT inducibility when compared to control animals."
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