IndraLab

Statements

PAN2 activates HIF1. 2 / 2
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"The P-body component USP52/PAN2 can enhance the stability of HIF-1α mRNA, which is crucial under hypoxic conditions (170)."
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"This process effectively maintains low levels of expression for these stemness-associated factors.239 Moreover, the stability of HIF protein can be regulated by DUBs such as USP8, USP19, and USP28.240, 241, 242 Additionally, USP52 plays a crucial role in the P-body complex to prevent degradation of HIF-1α mRNA.243 Inflammation."
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