IndraLab

Statements

CTNNB1 phosphorylates CTNNB1 on S33. 4 / 4
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reach
"This phosphorylation renders beta-catenin a primed substrate for glycogen-synthase kinase 3 (GSK3), which, in turn, continue to phosphorylate beta-catenin at T41, S37, and S33."
12507553
reach
"Previous studies have verified that the beta-catenin destruction complex mediates sequential phosphorylation of beta-catenin at S45, T41, S37 and S33 for subsequent ubiquitination and proteasomal degradation and thereby maintains low baseline cytosolic levels of the protein in cancer cells XREF_BIBR, XREF_BIBR."
29789528
reach
"In the absence of Wnt signaling, the beta-catenin destruction complex continuously phosphorylates beta-catenin protein at Ser 33, 37, 45 and Thr 41 to target beta-catenin for degradation via an ubiquitin dependent pathway XREF_BIBR, XREF_BIBR, XREF_BIBR."
25003522
sparser
"In the absence of Wnt signaling, the β-catenin destruction complex continuously phosphorylates β-catenin protein at Ser 33, 37, 45 and Thr 41 to target β-catenin for degradation via an ubiquitin-dependent pathway xref , xref , xref ."
25003522