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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CCND1 binds CDK4 and G1. 2 / 2

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"If the TAp73 and deltaNp73 isoform ratio is increased by miR-193a-5p in PCa cells, the expression levels of MDM2 and P21 (CDKN1A) might be elevated, and TP73 might function as a tumor suppressor, leading to the reduced effect of the CCND1 and CDK4 complex and G1 arrest."

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"CDKN1A (also called p21), which is a CDK inhibitor (CKI), can suppress the effects of the CCND1 and CDK4 complex in the G1 phase, leading to G1 arrest."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...