IndraLab

Statements

CCND1 binds CDK4 and G1. 4 / 4
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"In human hematopoietic stem cells, elevating the levels of CCND1–CDK4 complexes shortened the G1 cell cycle phase and promoted the G1–S phase transition [27]."
38546402
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"It could still be argued that whereas the only described function of the cdk4/cyclinD1 complex is to control G1 length, cyclins, as single molecules, might directly control differentiation [49] ."
20153966
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"If the TAp73 and deltaNp73 isoform ratio is increased by miR-193a-5p in PCa cells, the expression levels of MDM2 and P21 (CDKN1A) might be elevated, and TP73 might function as a tumor suppressor, leading to the reduced effect of the CCND1 and CDK4 complex and G1 arrest."
29467540
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"CDKN1A (also called p21), which is a CDK inhibitor (CKI), can suppress the effects of the CCND1 and CDK4 complex in the G1 phase, leading to G1 arrest."
29467540