IndraLab

Statements

Mutated TP53 binds MDM2. 18 / 18
| 18
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"However, these same p53 mutants formed a complex with MDM2 and were efficiently ubiquitinated, exported from the nucleus, and degraded when co-expressed with MDM2 and wild-type p53."
11572869
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"A p53 mutant that poorly binds Mdm2 undergoes deficient sumoylation."
15327968
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"The requirement of ROS for NSC59984-induced mutant p53 degradation raises another possibility that NSC59984 may mediate mutant p53 structure modifications with ROS which might be susceptible to the mutant p53 binding to MDM2 for further ubiquitination."
34992144
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"23 One of the key regulators of p53 function is MDM2, which also binds to mutant p53 through the N-terminal binding regions in both proteins."
25417702
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"Knock-down of HSP90 or pharmacologic inhibition with 17-allylamino-17-demethoxygeldanamycin (17-AAG) resulted in a release of Hsp90 from mutant p53 bound to MDM2 allowing ubiquitination and degradation [XREF_BIBR]."
24756955
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"Both mutant p53 and p73 bind MDM2 well, whereas p63 binds much more weakly."
25417702
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"65 Further advances in knowledge have demonstrated that MDM2 binds mutant p53 and vice versa, however, ubiquitination and degradation of mutant p53 is less efficient."
32041464
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"As MDM2 can bind both mutant p53 and TA/DeltaNp73alpha, these results indicate that p53/MDM2/p73alpha can form a trimeric complex, and that the p53 and TAp73alpha or p53 and DeltaNp73alpha interaction is enhanced by MDM2."
25417702
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"This is in agreement with previously reported observation that while the mutant p53 in HT29 cells can associate with MDM2, the E3 ligase had no effect on p53 stability ."
31772160
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"For this reason, MDM2 inhibitors have been proposed for inhibition of p53–MDM2 interaction and restoration of mutant p53 to wild-type p53 ( Nag et al., 2014; Hong et al., 2014 )."
25108507
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"The fact that the interaction between mutant p53 and MDM2 is dependent on the MDM2 RING domain rather than its E3 ligase [181] suggests that other E3 ligases are can ubiquitinate mutant p53."
33932560
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"Mutant p53 interacts with MDM2."
25888633
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"In many cases, even if MDM2 binds to mutant p53, it may not lead to the degradation of the mutated protein, allowing the aberrant p53 to accumulate in the cell."
39525665
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"However, mutant p53 still form complexes with MDM2, p21 and Slug, and resulted in no cell migration upon blocking neddylation."
| PMC
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"This process results in enhanced interaction of mutant p53 with MDM2 and CHIP, promoting ubiquitination and proteasomal degradation of mutant p53 (Wang et al., 2020)."
37502209
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"Here we show that in the mutant p53 and MDM2 complex, the mutant p53 core domain binds to the MDM2 acidic domain with significantly higher avidity compared to wild type p53."
30455251
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"Mutant p53 and MDM2 complex is deficient in catalyzing ubiquitin release from the activated E2 conjugating enzyme."
30455251
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"Upon combined ReACp53 and Nutlin -3 treatment, p53 levels were higher, supporting the idea that the now properly folded mutant p53 can interact with MDM2 (XREF_SUPPLEMENTARY)."
26748848