IndraLab

Statements

UCHL1 activates Carcinogenesis. 7 / 7
| 3 4
reach
"The experimental results of xenografts model in nude mice showed that UCHL1 promoted tumorigenesis of TNBC in vivo."
36434856
eidos
"This suggests that UCHL1 may act in cancer cells in both cell autonomous and paracrine manners to stimulate tumorigenesis ."
31857432
reach
"Moreover, UCH-L1 functions as an oncogenic factor via PI3K/Akt, MAPK/Erk and other signaling pathways to induce tumorigeneses numerous types of cancer, including breast cancer (17,29,88), NSCLC (19), lymphoma (31), parathyroid carcinoma (32,114), melanoma (33), cutaneous squamous cell cancer (34), osteosarcoma (35), uterine serous carcinoma (36) and neuroblastoma (37) (Table I)."
36844618
eidos
"Moreover , in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype117-119 , whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line117 ."
28959952
eidos
"The precise mechanism by which UCHL1 contributes to tumorigenesis remains unclear , although reports suggest that it contributes to cell survival signalling , cell cycle regulation , DNA repair and regulating pools of free ubiquitin in ways that affect protein degradation and function115 ."
28959952
reach
"Moreover, in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype 7–119, whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line ."
28959952
reach
"The precise mechanism by which UCHL1 contributes to tumorigenesis remains unclear, although reports suggest that it contributes to cell survival signalling, cell cycle regulation, DNA repair and regulating pools of free ubiquitin in ways that affect protein degradation and function ."
28959952