IndraLab

Statements

UCHL1 activates Carcinogenesis. 9 / 9
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"This suggests that UCHL1 may act in cancer cells in both cell autonomous and paracrine manners to stimulate tumorigenesis ."
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"Moreover, in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype 7–119, whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line ."
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"The precise mechanism by which UCHL1 contributes to tumorigenesis remains unclear , although reports suggest that it contributes to cell survival signalling , cell cycle regulation , DNA repair and regulating pools of free ubiquitin in ways that affect protein degradation and function115 ."
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"The precise mechanism by which UCHL1 contributes to tumorigenesis remains unclear , although reports suggest that it contributes to cell survival signalling , cell cycle Regulatory T cells ( T reg cells ) ."
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"The experimental results of xenografts model in nude mice showed that UCHL1 promoted tumorigenesis of TNBC in vivo."
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"The precise mechanism by which UCHL1 contributes to tumorigenesis remains unclear, although reports suggest that it contributes to cell survival signalling, cell cycle Regulatory T cells (T reg cells)."
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"The precise mechanism by which UCHL1 contributes to tumorigenesis remains unclear, although reports suggest that it contributes to cell survival signalling, cell cycle regulation, DNA repair and regulating pools of free ubiquitin in ways that affect protein degradation and function ."
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"Moreover, in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype 117-119 , whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line 117 ."
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"Moreover , in vitro tumorigenesis studies showed that UCHL1 expression stimulated oncogenesis and an invasive phenotype117-119 , whereas UCHL1 depletion had antitumour effects and blocked cell migration in a lung cancer cell line117 ."
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