IndraLab

Statements

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"A deficiency in USP25 potentiated LPS induced, but not poly (I : C)-induced, activation of NF-kappaB and MAPKs, as well as the production of proinflammatory cytokines."
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"To further confirm that USP25 inhibited the LPS induced activation of NF-kappaB and MAPKs, we performed electrophoretic mobility shift assays (EMSAs) with 32 P labeled consensus NF-kappaB and AP-1 (c-Jun-c-Fos) probes and showed that a deficiency in USP25 potentiated LPS induced, but not poly (I : C)-induced, activation of the transcription factors NF-kappaB and AP-1 (XREF_FIG)."
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"Because USP25 interacted with TRAF3 after stimulation with LPS and because the enzyme activity of USP25 was required for its regulation of TLR4 signaling (XREF_FIG and XREF_FIG), we hypothesized that USP25 might target TRAF3 for deubiquitination in response to LPS."
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