IndraLab

Statements

Phosphorylated CTNNB1 decreases the amount of CTNNB1. 5 / 9
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"In vitro, phosphorylation of beta-catenin induces the loss of membranous beta-catenin and E-cadherin, subsequently increasing the potential for metastasis."
23748820
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"GSK3 could phosphorylate Axin bound beta-catenin and then promote the rapid destruction of phosphorylated beta-catenin, preventing the transcription of beta-catenin target genes in the nucleus XREF_BIBR, XREF_BIBR."
29497056
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"Constitutive phosphorylation of beta-catenin by cyclin dependent kinase at serine 45 followed by phosphorylation of the N-terminus by GSK3beta targets beta-catenin for degradation by the ubiquitin and proteosome pathway, limiting levels of cytoplasmic beta-catenin under resting conditions."
20512915
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"This complex phosphorylates β-catenin, which downregulates cytosolic β-catenin levels ( Valenta et al., 2012 )."
32220599
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"Then, inhibition of beta-catenin phosphorylation raises the levels of beta-catenin in the cell and allows beta-catenin to enter the nuclei to bind to the transcription factor TCF/LEF, thereby initiating transcription of downstream target genes [XREF_BIBR]."
33712069