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FOXO1 increases the amount of FOXO1. 37 / 46
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"Increase of miR-155 significantly decreased forkhead box protein O1 (FoxO1) 3 ' UTR luciferase activity and expression and decrease of miR-155 notably increased FoxO1 expression."
26548866
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"Administration of an HSF diet blocked hyperacetylation of forkhead transcription factor 1 (FoxO1), a known target of sirtuin 1 (SIRT1), increased nuclear FoxO1 protein levels, and enhanced association of FoxO1 with the AdipoR2 promoter in the livers of ethanol fed mice."
21194380
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"These data suggested that when FSH signaling is absent, FoxO1 activates the transcription of FoxO1 and its downstream apoptotic genes, thereby triggering apoptosis in MGCs."
25321482
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"Importantly, FOXO1 KI increased the expression of FOXO1 and decreased the p-FOXO1 and total-FoxO1 ratio in the HG treated cells."
30962862
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"Indeed, using in vitro culture system, we found that macrophage Foxo1 and β-catenin colocalized in the nucleus, and increased nuclear expression of Foxo1 and β-catenin in response to LPS stimulation."
33288903
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"In this present study, we constructed osteoblast conditional FOXO1 knock-out mice and lentivirus-mediated FoxO1 overexpression to investigate maxillary titanium implant osseointegration."
34865256
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"In the presence of PsA, by either enforcing nuclear localization (PTEN null ishikawa cells) or increasing the already existing nuclear levels of FOXO1 (PTEN + ECC1 cells), FOXO1 triggered apoptosis."
19041124
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"Foxo1 negatively regulated pathogenic Th17 cell function and miR-183C promoted pathogenic cytokine expression of Th17 cells and repressed Foxo1 expression."
27332731
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"The ratio of P-Ser256 FOXO1 to total FOXO1 (a transcription factor involved in the regulation of GNG enzymes, including G6Pase and PEPCK) increased 3.0- and 3.6-fold in the 4x and 16x groups, respectively (XREF_FIG C), and analysis of total FOXO1 levels in nuclear enriched fractions detected reductions of 84 and 85%, respectively, compared with the control group (XREF_FIG C)."
19755527
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"It is able to induce apoptosis and inhibit proliferation in T790M positive NSCLC cell lines; upregulate the expression of forkhead box protein O1 (FoxO1); downregulate the long lncRNA colon cancer associated transcript 1 (CCAT1) levels in T790M positive NSCLC cell lines; and repress the tumor growth of T790M positive NSCLC xenografts [XREF_BIBR]."
| PMC
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"Consistently, SirT1 has been demonstrated to play a crucial role in repressing FoxO1 induced apoptosis and potentiating FoxO1 induced transcription of antioxidant and cell cycle arrest genes, including SOD2 and p27Kip1 XREF_BIBR."
20668652
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"Collectively, our data indicated that FoxO1 enhanced the expression of FoxO1 and its downstream apoptotic gene, thus leading to apoptosis in MGCs."
25321482
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"XREF_BIBR, XREF_BIBR, XREF_BIBR As all FoxO family members have a consensus DNA binding sequence known as FRE, 15 we hypothesized that FoxO1 triggered apoptosis by upregulating FoxO1 expression in MGCs of DFs when FSH signaling was absent."
25321482
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"Interestingly, we found that inhibition of Smad3 activity prevented the increase in Foxo1 expression mediated by TGF-beta1 treatment confirming the implication of TGF-beta1 and Smad3 signaling in Foxo1 expression."
29339772
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"By chromatin immunoprecipitation FOXO1 was shown to bind to the MMP9 promoter, FOXO1 overexpression increased MMP9 transcriptional activity and increased MMP9 expression stimulated by high glucose was blocked by FOXO1 deletion or FOXO1 knockdown."
28874756
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"Carmustine but not the other two alkylating agents showed some dependency on FoxO1 in its killing RD-ES, which was consistent with the fact that cisplatin and temozolomide did not cause significant changes in the mRNA levels of FoxO1 while carmustine could significantly increase the mRNA levels of FoxO1 at 50 μM (Fig. 5g)."
31992690
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"Furthermore, inhibition of FoxO1 in PA untreated cells induced cell death, inhibited autophagic flux, and inhibited FoxO1 and PXDN expression."
33903591
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"2-hydroxyglutarate levels were also higher when FOXO1 levels were induced by a physiological quiescence and FOXO1-inducing signal, contact inhibition."
33795872
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"Future studies will determine whether the differential Foxo1 expression between MPECs and SLECs is caused by differences in Foxo1 stability as a consequence of Akt induced phosphorylation."
23932570
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"Furthermore, the inhibition of Foxo1 transcription by actinomycin D blocked induction of FOXO1 protein levels by cAMP (XREF_FIG c)."
24379407
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"In mice not stressed by insulin resistance, acute deletion of Foxo1 does not significantly reduce the expression of Foxo1 target genes (XREF_FIG), although chronic deletion of multiple Foxo family members including Foxo1 results in modest reduction of expression of these genes XREF_BIBR, XREF_BIBR."
22344295
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"In addition, deacetylation of FoxO1 by Sirtuin 1 (SIRT1) promotes FoxO1 mediated transcription of target genes, such as SOD2 [XREF_BIBR]."
24633153
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"The present study reported that knockdown of FOXO1 expression by FOXO1 small interfering RNA resulted in a reduction of ChREBP protein expression and post-transcriptional activity."
32705195
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"To determine the biological role of FOXO1 in CIH mediated apoptosis of cardiomyocytes, siRNA targeting FOXO1 was utilized to disrupt the expression of FOXO1."
28738025
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"Investigating the role of insulin–PI3K–Akt signalling in this pathway, in FoxO1-clover reporter podocytes [21] both FoxO1 inhibition with AS1842856 and insulin stimulation reduced the nuclear levels of FoxO1 (Fig. 3a–c) and increased FoxO1 phosphorylation (Fig. 3d)."
33758952
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"In comparison with the model group, the levels of body mass, SOD activity, and FoxO1 and PGC-1α expression were significantly increased in the three treatment groups except SOD, expression of FoxO1 and PGC-1α in the inhibitor group ( P <0.01, P <0.05), and the contents of blood glucose, Scr, BUN, ALB, MDA and ROS were obviously decreased in the three treatment groups except ALB and ROS in the inhibitor group ( P <0.01, P <0.05)."
35616418
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"Concordantly, PANDER overexpression in liver promoted lipogenesis, lipid accumulation, and Forkhead box 1 (FOXO1) expression, Furthermore, overexpression of FOXO1 concordantly increased hepatic PANDER levels [XREF_BIBR]."
21664909
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"Figure XREF_FIG demonstrates that the WT-FoxO1 vector effectively upregulated the expression of FoxO1 while producing little change in the NC group."
| PMC
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"Phosphorylation of FoxO1 at Thr24, Ser256, and Ser319 (TSS) can promote its nuclear to cytoplasmic translocation and inhibit FoxO1 dependent transcription."
32191993
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"In addition, the FTO induced expression of forkhead box protein O1 (FOXO1), glucose-6-phosphate (G6P), and diacylglycerol O-acyltransferase 2 (DGAT2) correlated with elevated serum glucose levels in human patients 53."
31475777
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"EGCG induced nuclear exclusion of FOXO1, FOXO1 binding to the hET-1 promoter, and reduction of ET-1 expression was partially inhibited by the AMPK inhibitor Compound C. Basal ET-1 protein expression was enhanced by short interfering RNA knock-down of Akt and reduced by short interfering RNA knock-down of FOXO1 or adenovirus mediated expression of dominant negative Foxo1."
19887561
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"Deacetylation of Foxo1 by Sirt1 promotes Foxo1 dependent transcription and accelerates Foxo1 degradation."
19817786
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"Figure 4(a) showed that SREBP-1c could inhibit FoxO1 expression (fold change ≈ 1.65), and FoxO1 also inhibited SREBP-1c expression (fold change ≈ 1.39)."
34539243
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"In this study, we show that an S209A phospho-null Foxo1 exhibited Akt dependent nuclear trafficking in mouse CD8 T cells and augmented the expression of canonical Foxo1 target genes such as Il7r and Sell In contrast, an S209D phosphomimetic Foxo1 (SD-Foxo1) was largely excluded from the nucleus of CD8 T cells and failed to transactivate these genes."
33229443
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"Intriguingly, recent evidence suggests that the posttranslational control of FoxO1 can influence FoxO1 transcription."
20668652
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"XREF_FIG a, Adv-null did not alter the expression of FoxO1, while Adv-FoxO1 effectively upregulated the expression of FoxO1 in primary microglia."
| PMC
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"The result indicated that the overexpression vector of FoxO1 significantly increased the expression of FoxO1 compared with pcDNA3.1 (XREF_FIG)."
27936150