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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MTOR activates SRC. 2 / 2

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"Phosphorylation of extracellular signal regulated kinase (ERK) (pERK), p38 mitogen activated protein kinase (MAPK), pSRC, phosphorylation of signal transducer and activator of transcription factor 1 (pSTAT1), pSTAT3, and pSTAT5 was very low to moderate in murine and human RMS cells and was not decreased by GSK212 treatment (XREF_SUPPLEMENTARY), suggesting that PI3K and mTOR signaling does not activate RAS and MAPK, SRC, or Janus activated kinase signaling in these cells."

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"The latter should be accomplished indirectly through mTOR mediated Src kinase activation since mTOR is a serine/threonine and not a tyrosine protein kinase."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...