IndraLab

Statements

JQ1 inhibits IFNB1. 2 / 2
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"Similar to the TLR3-TBK1-IRF3 pathway, we found that BI-2536, JQ1 and I-BET151 blocked the TLR7- or TLR9 stimulated secretion of IFNbeta in Gen2.2 cells (XREF_FIG A and XREF_FIG B), without affecting the TLR stimulated translocation of the endogenous IRF5 to the nucleus (XREF_FIG C)."
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reach
"Since BI-2536 and JQ1 blocked IFNbeta production by preventing the interaction of transcription factors with the Ifnb promoter, it was of interest to examine the effects of these compounds on the transcription of other poly (I : C) - and LPS regulated genes."
25891802