IndraLab

Statements

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"Our previous results showed that UCHL5 promoted the glycolysis of HCC cells."
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"UCHL5 promotes hepatocellular carcinoma progression by promoting glycolysis through activating Wnt/beta-catenin pathway."
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"In hepatocellular carcinoma, UCHL5 promotes glycolysis through activation of the Wnt/β-catenin pathway and thus promotes hepatocellular carcinoma progression [38]."
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"UCHL5 promotes glycolysis of HCC cells."
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"The findings demonstrated that the glycolysis route underwent the greatest multiple of change (Fig. 3A), which led us to speculate whether UCHL5 promoted tumor progression by regulating the glycolysis process."
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"These findings imply that UCHL5 promotes tumor cell glycolysis, and the drop in intracellular metabolites and ATP following UCHL5 knockdown supports this hypothesis."
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"Our study’s findings demonstrate that altering UCHL5 expression can control the mRNA expression levels of markers associated with metabolism, including GLUT1, PKM2, HK2, and LDHA, and further encourage the growth of glycolysis.In this work, we discovered that UCHL5 triggers Wnt/β-catenin to activate glycolysis."
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"The final intuitive effect is that high UCHL5 expression promotes glycolysis of HCC cells to provide energy for the proliferation and metastasis of HCC cells, this is unreported in earlier investigations."
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"First, we discovered that UCHL5 stimulates the Wnt/β-catenin pathway in tumor cells to enhance glycolysis."
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