IndraLab

Statements

BAP1 activates Carcinogenesis. 5 / 5
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"BAP1 PGVs accelerate mesothelioma tumorigenesis after asbestos exposure in preclinical models and may be partly predicted by clinical criteria."
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"While RNF2, through H2A monoubiquitination, silences the BCL2 and MCL1 prosurvival genes and thereby induces apoptosis in some cell types, this does not occur in melanocytes, suggesting that BAP1 promotes tumorigenesis in cells that do not engage such RNF2 apoptotic programme.Moving to the p53 tumor suppressor, Karen Vousden (London, UK), who was awarded the CDD Award 2018, retraced the long road leading to her key discoveries of p53 functions."
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"Besides, a study of families with BAP1 germline mutations shows that mutated BAP1 may promote oncogenesis and increase the risk of KIRC by 8-fold through altering cellular metabolism and the tumor microenvironment (25)."
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"For instance, in the ~40% of tumors that are seemingly wild-type for both PBRM1 and BAP1, what other events cooperate with VHL loss to promote oncogenesis?"
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"Among them, BAP1 and BLM are present as a germline inactivation in a small subset of patients and increases predisposition to tumorigenesis."
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