IndraLab

Statements

STAMBP activates MC4R. 3 / 3
| 1 2
sparser
"ACTH (1–39) or α-MSH can activate MC1R, MC3R, MC4R, and MC5R ( xref ), but MC2R can only be activated by ACTH and not by α-MSH or other analogs ( xref )."
28228747
reach
"Of interest, if synaptic plasticity is the primary means by which aMSH activates PVH MC4R neurons and causes satiety, then it would explain why alphaMSH and MC4R signaling is so necessary on the one hand, and why alphaMSH release by ARC POMC neurons is generally so insufficient on the other hand."
28817798
sparser
"ACTH can activate all five receptor subtypes; of the melanocortins, only ACTH activates MC2R; ACTH as well as α-MSH, β-MSH and γ-MSH activate MC1R, MC3R, MC4R and MC5R, although with varying affinities."
28805746