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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mutated ATXN3 activates MBNL1. 1 / 1

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"The most recent results from our laboratory show that in human HD and SCA3 fibroblasts, the expression of endogenous HTT and ATXN3 mutant transcripts causes the formation of CAG repeat foci and MBNL1 sequestration, which in turn trigger the aberrant splicing of endogenous sarco and endoplasmic reticulum Ca2+ ATPase 1 (SERCA1) and INSR transcripts."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...