IndraLab

Statements

MTORC1 decreases the amount of IRS1. 12 / 12
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"Consistent with previous studies demonstrating that chronic mTORC1 activation decreases both the expression and stability of IRS-1 and IRS-2 XREF_BIBR, XREF_BIBR, XREF_BIBR, we find that 24 h treatment with rapamycin increases Irs-1 and Irs-2 transcript levels and IRS-1 protein levels in Tsc2 -/- adipocytes, albeit to levels still significantly lower than Tsc2 +/+ adipocytes (XREF_SUPPLEMENTARY, panels A and B)."
19593385
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"Moreover, inhibition of mTORC1 with either rapamycin or raptor knockdown did not elevate IRS-1 levels, despite potently increasing Akt phosphorylation."
28831455
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"Consistent with previous findings [XREF_BIBR], inhibition of mTORC1 by raptor knockdown or short-term rapamycin treatment slightly enhanced IRS-1 expression."
23863152
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"The feedback observed in EGFR and HER2 driven cancers is distinct from a well described feedback mechanism in which mTORC1 inhibition leads to increased IRS-1 expression and up-regulation of IGF-IR and IRS signaling."
22552284
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"The continuous activation of mTORC1 in cultured cells suppresses insulin dependent activation of PI3K by downregulating IRS1 (insulin receptor substrate-1) gene expression or by inhibitory phosphorylation of IRS-1."
19177005
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"Inhibition of mTORC1 with rapamycin has been known to increase IRS-1 levels and induce AKT phosphorylation and downstream signaling [XREF_BIBR]."
24265156
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"Chronic activation of S6K1 and mTORC1 promotes IRS-1 degradation via phosphorylation of Ser265, 307, 522, and 636 and inhibits IRS-1 transcription (Copps and White, 2012)."
25813876
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"AMPK inhibits mTORC1 via raptor or TSC phosphorylations [XREF_BIBR, XREF_BIBR] and supports IRS-1 and Akt expressions."
28035937
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"First, S6K, a substrate of mTORC1, decreases the activity and protein levels of IRS1 by phosphorylating it (Harrington et al., 2004; Um et al., 2004; Shah et al., 2004)."
34869377
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"Direct inhibition of mTORC1 with rapamycin blocks S6Kinase dependent feedback inhibition of IRS-1 expression and activates IGF-1R signaling."
21215704
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"Specifically, mTORC1 impairs PI3K activation in response to growth factors by downregulating the expression of Insulin Receptor Substrate 1 and 2 (IRS-1/2) and Platelet Derived Growth Factor Receptor-Beta (PDGFR-beta) (reviewed in)."
19446321
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"Further, AKT activates TORC1 and S6K, which repress IRS1 expression in order to regulate pathway signaling output."
30867161