IndraLab

Statements

PPP3 binds KCNK18. 9 / 10
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sparser
"The activated calmodulin complex stimulates the binding of calcineurin to the TRESK intracellular loop, thus promoting dephosphorylation of the two regulatory residues (Ser252 and the serine cluster) and the activation of the channel."
34199759
sparser
"General regulation of TRESK by calcineurin is in good accordance with the previous result that TRESK and calcineurin are associated via direct protein-protein interaction xref ."
22145024
reach
"We were unable to find a significant association between TRESK and calcineurin by double immunofluorescence."
26256973
reach
"However, we were unable to find a significant association between TRESK and calcineurin by double immunofluorescence (Fig. 7)."
26256973
reach
"Further, application of cyclosporin A or VIVIT peptide, which inhibits the interaction between calcineurin and TRESK at an NFAT like docking site, 23 reversed the abnormal electrophysiological properties of NG neurons from 8-wk STZ-D rats."
27475306
sparser
"VIVIT peptide appears to inhibit the calcineurin–TRESK protein interaction at an NFAT-like docking site. xref , xref Superfusion of VIVIT peptide (0.3 μM, n = 6) depolarized NG neurons from 8-wk STZ-D rats ( xref ) and restored their excitability."
27475306
sparser
"Further, application of cyclosporin A or VIVIT peptide, which inhibits the interaction between calcineurin and TRESK at an NFAT-like docking site, xref reversed the abnormal electrophysiological properties of NG neurons from 8-wk STZ-D rats."
27475306
sparser
"Coexpression of a constitutively active form of calcineurin with TRESK increased the basal background K(+) current and attenuated the response of the channel to the calcium signal, indicating that TRESK was activated by the permanent calcineurin activity."
14981085
sparser
"In the present study we report that calcineurin also interacts with TRESK via an NFAT-like docking site, in addition to its enzymatic action."
16569637