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PPP3 binds KCNK18. 13 / 14
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"We were unable to find a significant association between TRESK and calcineurin by double immunofluorescence."
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"However, we were unable to find a significant association between TRESK and calcineurin by double immunofluorescence (Fig. 7)."
26256973
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"A PxIxIT docking site also mediates calcineurin interaction with the TRESK K + channel substrate ( Czirjak and Enyedi, 2006 )."
17386265
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"General regulation of TRESK by calcineurin is in good accordance with the previous result that TRESK and calcineurin are associated via direct protein-protein interaction xref ."
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"The interaction of calcineurin and TRESK contributes to the development of pain by regulating the excitability of sensory neurons and nociceptors (Fig. 2) [19, 29, 32]."
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"VIVIT peptide appears to inhibit the calcineurin–TRESK protein interaction at an NFAT-like docking site. xref , xref Superfusion of VIVIT peptide (0.3 μM, n = 6) depolarized NG neurons from 8-wk STZ-D rats ( xref ) and restored their excitability."
27475306
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"Further, application of cyclosporin A or VIVIT peptide, which inhibits the interaction between calcineurin and TRESK at an NFAT-like docking site, xref reversed the abnormal electrophysiological properties of NG neurons from 8-wk STZ-D rats."
27475306
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"In the present study we report that calcineurin also interacts with TRESK via an NFAT-like docking site, in addition to its enzymatic action."
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"A PxIxIT docking site also mediates calcineurin interaction with the TRESK K + channel substrate ( Czirjak and Enyedi, 2006 )."
17386265
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"Coexpression of a constitutively active form of calcineurin with TRESK increased the basal background K(+) current and attenuated the response of the channel to the calcium signal, indicating that TRESK was activated by the permanent calcineurin activity."
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"The interaction of calcineurin and TRESK contributes to the development of pain by regulating the excitability of sensory neurons and nociceptors (Fig.  xref ) [ xref , xref , xref ]."
40091077
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"Further, application of cyclosporin A or VIVIT peptide, which inhibits the interaction between calcineurin and TRESK at an NFAT like docking site, 23 reversed the abnormal electrophysiological properties of NG neurons from 8-wk STZ-D rats."
27475306
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"The activated calmodulin complex stimulates the binding of calcineurin to the TRESK intracellular loop, thus promoting dephosphorylation of the two regulatory residues (Ser252 and the serine cluster) and the activation of the channel."
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