IndraLab
Statements
reach
"In this study, we illustrated that IL-37b could suppress transcriptional levels of PYCARD, S100A9, and CAMP genes, and antagonize the activation of NF-kappaB, PI3K-Akt, and ERK1/2 pathways in eosinophils, which elucidate the intracellular signaling cascade to suppress the bacterial TLR2 mediated activation in eosinophils upon interaction with human bronchial epithelial cells, and ameliorate the exacerbated allergic airway inflammation in HDM humanized asthmatic mice."
reach
"Preliminary experiments regarding the crosstalk between MAPKs and STAT3 signaling pathways are currently under investigation to clarify this detailed mechanism of the in vivo mouse model as well as the in vitro cell culture system.In conclusion, we demonstrated that S100A9, one component of calprotectin, activates p38, ERK, and STAT3 signaling pathways, resulting in increased IL-6 and RANKL expressions in mouse osteocyte-like cells."