IndraLab

Statements


IL1B increases the amount of CD4. 5 / 5
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"Conversely, neither LPS nor TNF-alpha and IL-1 beta were able to modulate surface CD4 expression on quiescent or phytohaemagglutinin (PHA)-activated lymphocytes."

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"We showed here that effector CD4 + T cells induced IL-1beta transcription and cleavage in interacting MPs, including macrophages and DCs, in a TNFR-Fas-dependent manner."

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"However, after 24h, IL-1beta significantly increased surface expression of the positive CD4 + T-cell co-stimulatory molecule, ICOS-L 57."

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"CD4+CD25+ cells from S. Enteritidis- and S. Heidelberg-infected chickens and restimulated with 1 μg antigen in vitro, had higher (P < 0.05) IL-10 mRNA transcription than the CD4+CD25+ cells from the non-infected controls Though at 4dpi, chickens infected with S. Enteritidis and S. Heidelberg had a significant (P < 0.05) increase in CD4+CD25- IL-2, IL-1β, and IFNγ mRNA transcription, the CD4+CD25- IL-2, IL-1β, and IFNγ mRNA transcription, were comparable to that in the control group at 11 and 32dpi identifying that the host inflammatory response against Salmonella disappears at 11 dpi."

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"This down-regulation of CD4 expression by LPS, TNF-alpha, and IL-1 beta occurs at the level of transcription."