IndraLab

Statements

Beta2 subunit activates KCNMA1. 6 / 6
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"The beta2 subunit induces the BK channel inactivation with the coexpressed alpha-subunit leading to neuronal excitability by inhibiting K + currents."
28131462
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"When studying the modulation of Slo1 by beta2 subunit, it is important to saturate the beta2 expression to get stable results."
27755549
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"Specifically, the diurnal changes that occur in the SCN may be attributable to a voltage shift of the BK channel activation curve produced by the beta2 subunit rather than inactivation of the BK channel which, additionally, appears to occur outside of the range of membrane potentials spanned by an AP."
29084840
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"Furthermore, addition of a synthetic N-terminal peptide of the beta2 subunit causes inactivation of the MaxiK channel alpha subunit by occluding its K +-conducting pore resembling the inactivation caused by the " ball " peptide in voltage dependent K+ channels."
10097176
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"The beta2 subunit induces the BK channel inactivation with the coexpressed alpha-subunit leading to neuronal excitability by inhibiting K + currents (Wallner et al., 1999)."
28131462
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"In this study, we identified the regions in Slo1 targeted by the beta2 subunit modulation by taking advantage of different responses of two BK channel homologues, mSlo1 and dSlo1, to the beta2 subunit modulation."
21123563