IndraLab

Statements

USP10 binds TOP2alpha. 4 / 4
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"In this study, we also report that in addition to RNF168, TOP2alpha also interacts with USP10."
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"Given that our mass spectrometry analysis identified USP10 as a possible RNF168 interacting partner (XREF_SUPPLEMENTARY), we hypothesized that USP10 and RNF168 forms a complex with TOP2alpha to co-regulate its ubiquitylation level."
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"These novel functional interactions between RNF168, TOP2alpha and USP10 are likely to contribute to the maintenance of chromosomal integrity."
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"Finally, we show that the deubiquitylase USP10 interacts with RNF168 and TOP2alpha, and restrains ubiquitylation of TOP2alpha as well as its chromatin binding."
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