IndraLab

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USP10 increases the amount of SMAD4. 2 / 2
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"We found that depletion of USP10 using USP10‐specific shRNA in HepG2 and Bel‐7402 cells significantly decreased Smad4 protein levels, but had little effect on Smad2/3 protein levels (Fig. 2A,B and Fig. S3A)."
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"Conversely, overexpression of USP10‐WT (the wild‐type of USP10) but not USP10‐C424A (the catalytically deficient mutant of USP10) in HepG2 and Bel‐7402 cells dramatically increased the protein levels of Smad4, but not that of Smad2/3 (Fig. 2C,D and Fig. S3C)."
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