IndraLab

Statements

reach
"Different NLRP3 inflammasome inhibitors, including sulforaphane, β-hydroxybutyrate, glyburide, flufenamic acid, mefenamic acid, parthenolide, BAY 11-7082, INF39, and MCC950 have been developed, but there is no evidence demonstrating that these compounds directly and specifically target NLRP3 itself (212)."
30619282
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"Various Cl - channel inhibitors, including 4,4 '-diisothiocyano-2,2 ' stilbene-disulfonic acid (DIDS), 5-nitro-(3-phenylpropylamino) benzoic acid (NPPB), flufenamic acid, mefenamic acid, and indanyloxyacetic acid 94 (IAA94), block the NLRP3 inflammasome but can not block the NLRC4 or AIM2 inflammasomes."
33603747
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"A few NLRP3 inflammasome inhibitors, including sulforaphane, isoliquiritigenin, beta-hydroxybutyrate (BHB), flufenamic acid, mefenamic acid, 3,4-methylenedioxy-beta-nitrostyrene (MNS), parthenolide, BAY 11-7082, INF39, and MCC950, have been developed, but there is no evidence showing that these compounds can specifically and directly inhibit NLRP3 itself."
29021150
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"Daniels et al. demonstrated that the nonsteroidal anti-inflammatory drugs flufenamic acid, meclofenamic acid and mefenamic acid inhibited the NLRP3 inflammasome by inhibiting volume-regulated anion channels in macrophages, and mefenamic acid ameliorated Alzheimer’s disease in a mouse model (39)."
35669789
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"In addition, flufenamic acid (FA), a member of non-steroidal anti-inflammatory drugs, was found to effectively inhibit activation of the microglial NLRP3 inflammasome by regulating Syk and AMPK."
35474599
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"This signaling induces mitochondrial fragmentation and generation of ROS, thereby activating the NLRP3 inflammasome.In addition, this signaling pathway is inhibited in microglia by flufenamic acid (FA), a type of non‐steroidal anti‐inflammatory drugs (NSAIDs), thereby regulating the Aβ‐induced activation of microglial inflammasome."
35474599
reach
"Flufenamic acid and mefenamic acid inhibit NLRP3 inflammasome activation through the suppression of chloride efflux."
29021150
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"The fenamates, mefenamic acid and flufenamic acid, inhibit the NLRP3 inflammasome in rodent models [88]; however, the limited use of NSAIDs throughout pregnancy [82] has restricted their development as treatments for placental inflammation."
40260875
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"XREF_BIBR Cl - channel blockers such as mefenamic acid, flufenamic acid, benzoic acid, etc, can inhibit the NLRP3 activation."
33814921