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NGF activates cell differentiation. 1000 / 2283
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"Research has demonstrated that NGF participates in the repair process of corneal epithelial and stromal damage by upregulating matrix metalloproteinase-9 (MMP-9) and cleaving integrins β4 to stimulate the migration of corneal epithelial cells, promotes the differentiation of keratocytes into myofibroblasts, and reduces the formation of corneal haze (83–85)."
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"Within this context, the ligation of active NGF by TrkA protects neuroblasts against apoptosis and promotes differentiation; pro form NGF, in the absence of TrkA, promotes neuroblast apoptosis via the low-affinity NGF receptor p75 NTR and sortilin, and in the absence of NGF, TrkA recruits p75 NTR as a hired killer to induce neuroblast apoptosis."
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"Our results suggest that (1) different receptor tyrosine kinases use similar patterns of activation of signaling pathways to mediate distinct biological outcomes of cell migration and proliferation, (2) NGF activates signaling proteins in smooth muscle cells similar to those activated during NGF induced neuronal differentiation, and (3) the combinatorial effects of different signaling pathways are important for the regulation of smooth muscle cell migration and proliferation."
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"Overall, the results of the PC12 cell growth, proliferation and differentiation analysis at the three different cell culture conditions seem to be in general agreement (XREF_FIG) with what has previously been reported, i.e. that NGF promotes neuronal differentiation associated with neurite extensions XREF_BIBR, XREF_BIBR."
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"Since the processesinduced by NGF are significantly longer than those induced by 0X-7, the mAb appears to initiate neurite sprouting, but is not capable of inducing the outgrowth of long processes that accompanies NGF induced differentiation to a fully neuronal phenotype.Multivalent anti-Thy-l mAbs are necessaryfor neurite induction."
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"In addition, nerve growth factor (NGF) stimulates axon growth and differentiation of neural stem cells (NSCs) [8, 9]; exogenous NGF can supplement endogenous neuronutrients during SC tissue repair, but multiple administrations are required because of its short half-life in vivo for 4 h [10]."
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"In rat pheochromocytoma (PC-12) cells, which have been used as an in vitro model system to study the mechanisms of neuronal differentiation, NGF induces their differentiation, leading to the extension of neurites and the development of the characteristics of sympathetic neurons [XREF_BIBR]."
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"Thus, some groups tested this combination and showed that MSCs along with either nerve growth factor (NGF) (Huang et al., 2006) or basic fibroblast growth factor (Kim et al., 2006) can promote axonal regeneration, cell differentiation, and functional recovery in adult rats after SCI."
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"Similar to inactivation of
VHL, inactivation of TFAM upon
transduction with an effective shRNA, PC12 cell showed no characteristics of
phenotypical changes associated to NGF induced differentiation (Fig. 7d, e), indicating that low
mitochondrial content prevents neural differentiation induced by NGF."
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"From the in vitro culture of muscle derived stem cells, it was observed that the NGF immobilized microspheres induced more neurogenic differentiation than the bFGF immobilized microspheres, as evidenced by a quantitative real-time polymerase chain reaction using specific neurogenic markers (Nestin, GFAP, beta-tubulin, and MAP2) and Western blot (Nestin and beta-tubulin) analyses."
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"As mentioned above, the suspension PC12 cells cannot adhere to the plastic surface; therefore, it is required to increase the surface of the differentiation vessels.After strong adhesion of suspension PC12 cells that were also treated with 50 ng/ml NGF for stimulating PC12 cell differentiation."
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"NGF is a trophic factor that promotes several activities, including signaling, apoptosis, and neuronal differentiation.24 Following NGF treatment, PC12 cells obtain sympathetic neuron-like phenotypic properties, which include the discontinuation of cell proliferation.25 Being a neural-like cell line, PC12 could be sub-cultured, allowing experiments with repeatability; also, PC12 cells respond to NGF in a cell cycle-specific manner, and the p53 gene plays a role in NGF-mediated differentiation by inducing cell cycle arrest.26 27NGF is a polypeptide neurotrophic factor that activates the trombomyosin receptor kinase A (TrKA) to alleviate cell transition from proliferation to differentiation."
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"In our text mining study, Hia has been linked to nerve growth factor (NGF), a homodimeric protein that acts as a mediator of inflammation in injured tissues, induces neuronal differentiation, promotes neuronal survival and prevents apoptosis in neurons of both central and peripheral nervous systems."
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"NGF supports neuronal growth, survival, and differentiation [52], restoring the function of injured neurons [6], and has been investigated as a novel treatment strategy both in experimental animal models and in TBI patients.There are several hypotheses to explain why NGF exerts beneficial effects in traumatic brain injury [53, 54]."
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"The present set of experiments demonstrate that alcohol reduces PC12 cell numbers at phar-macologically relevant concentrations; that NGF induced differentiation of PC12 cells results in less severe alcohol induced reductions in cell numbers; and that undifferentiated cells in which proliferation is arrested undergo significant cell loss, but which is less severe than in proliferating cultures."
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"length and number of neurites),64,65,80 changes in the intracellular molecular content have only been separately determined by HPLC or electrochemical methods on cell lysates.73,78,81,82 Molecular imaging of PC12 cells using CAP488 will therefore establish a direct correlation of the dopamine dynamics with the NGF-stimulated differentiation process."
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"To determine the effect of NGF on DPSCs proliferation, we treated DPSCs with NGF (50 ng/mL) for 1–7 days and found that the proliferation activity of DPSCs in the presence of 50 ng/mL NGF increased gradually in a time‐dependent manner by using CCK‐8 test (Figure S1).3.3
NGF promoted osteogenic differentiation of DPSCs
."
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"To assess the role of PLC-gamma1 in mediating the neuronal differentiation induced by NGF treatment, we established PC12 cells that overexpress whole PLC-gamma (PLC-gamma1PC12), the SH2-SH2-SH3 domain (PLC-gamma1SH223PC12), SH2-SH2-deleted mutants (PLC-gamma1deltaSH22PC12), and SH3 deleted mutants (PLC-gamma1deltaSH3PC12)."
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"In the current study, we firstly investigated whether BM-MSCs from NOD mice could effectively differentiate into retinal cells by using a cocktail of brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and basic fibroblast growth factor (bFGF), which could induce MSCs differentiation into retinal neuron like cells."
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"Thus, signaling molecules that have been shown to function in other growth factor regulated systems similarly play critical roles in NGF induced differentiation of PC12 cells.In this report, we demonstrate that NGF induced tyrosine phosphorylation of MAPKs is dependent on the activityof Ras in PC12cells."
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"Some studies showed that, as a potent promoter of mineralization during dentin formation, NGF significantly stimulates DNA synthesis and mineral deposition in cultures of human pulp cells, and induces differentiation of odontoblast-lineage cells with subsequent biomineralization in vitro[24], [25], [26]."
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"NGF was transported retrograde along the axon of dorsal root ganglion and supported dorsal root ganglion survival and differentiation (Sung et al., 2018), a function likely attributed to TrkA.We tested the ability of NGF to elicit painful responses both in vitro and in vivo, using NGF as a comparison."
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"Silencing of FEZ1 by RNA interference (RNAi) strongly inhibited the NGF induced differentiation and efficiently reduced the anterograde transport of mitochondria in PC12 cells, suggesting that FEZ1 is essential for NGF induced neuronal differentiation of PC12 cells XREF_BIBR, XREF_BIBR."
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"Additionally, our data provide the first information on the molecular mechanisms regulating the expression of shootin1 gene : NGF activates the TrkA receptor tyrosine kinase, which results in the activation of a number of intracellular signalling pathways, including PI3K that induces protein expression of isoform-2 of shootin1 only during NGF mediated differentiation of PC12 cells."
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"While 20 ng/mL of NGF significantly induces neurite outgrowth in PC12 cells (21.06 ± 1.27%), 43 at 50 μmol/L and 100 μmol/L almost completely inhibits NGF-induced axonal growth in PC12 cells, demonstrating that 43 can effectively suppress NGF-induced neuronal differentiation in PC12 cells without killing them (Liu et al. 2012)."
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"The results indicate that coexpression of both low- and high-affinity NGF receptors are not only more efficient in restoration of NGF induced differentiation pathway, but also be able to activate the pro apoptotic activity of low-affinity NGF receptor and make the tumor cells become NGF dependent and irreversibly differentiated."
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"Several of these stimuli promote the production of different trophic factors such as brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), nerve growth factor (NGF) or vascular endothelial growth factor (VEGF), which mediate the proliferation, differentiation and survival of the NSPCs; some of them are also involved in synaptogenesis (37, 41, 42)."
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"Although conditioned medium that regulates chondrogenesis of MSCs has been well established (7), the high cost, short half-life, versatility and functional heterogeneity of traditional growth factors remain an obstacle for stem cell-based therapy.In our previous study, it was revealed that a novel growth factor, nerve growth factor (NGF) extracted from Chinese cobra venom, specifically induces the chondrogenic differentiation of MSCs and further promotes cartilage repair (8)."
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"The present data thus show that NGF induces the differentiation of GH-3 cells into one of their physiological counterparts, the mammotroph cell, and together with the finding that NGF receptors are expressed in the anterior pituitary suggest a physiological role for the neurotrophic factor in pituitary ontogenesis."
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"In contrast, the v-erbA oncogene, a mutated, oncogenic version of TR alpha-1, partially but constitutively inhibited NGF- induced neuronal differentiation of PC12 cells and potentiated dexamethasone induced chromaffin differentiation, giving rise to an aberrant " interlineage " cell phenotype."
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"For instance, in neuronal precursor cells, epidermal growth factor (EGF) induces a transient response of the mitogen-activated protein kinase (MAPK) pathway and cell proliferation, whereas neuronal growth factor (NGF) triggers neuronal differentiation by means of sustained MAPK signaling (12)."
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"Recently, their secreted factors have shown therapeutic potential in various diseases.41,42 The differentiation process is often influenced by the scaffolds and growth factors used, eg, embedded collagen/chitosan scaffolds promote dentin differentiation of DPSCs,52 a bioengineered scaffold provided by porcine decellularized dental pulp has also been found to have a pro-dentin/enamel differentiation effect,53
transforming growth factor (TGF-β) enhances the proliferation and chondrogenic differentiation of DPSCs,55 and nerve growth factor (NGF) affects the neurogenic ability of DPSCs."
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"Exposure of PC12 cells to NGF triggers differentiation into sympathetic like neuronal cells, characterized by long-term and stable neurite outgrowth and exhibiting many properties of adrenal medullary chromaffin cells, including catecholamine synthesis, storage, and secretion XREF_BIBR."
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"Since CREB is believed to be the transcription factor that can integrate Ca2+, growth factor and cAMP induced signals, we suggest that p90Rsk may be one of the kinases which is able to replace ERKs under certain circumstances, thereby participating in Ras independent neuronal differentiation induced by NGF plus ionomycin."
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"Intestinal epithelial cells have been shown to produce neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) (Liu, 2018; Singh, 2023), especially BDNF, can efficiently promote the differentiation of SH-SY5Y cells (Bilginer Kartal and Arslan Yildiz, 2024)."
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"Early insights into ERK signal specificity came from studies of the PC12 rat pheochromocytoma cell line in which it was shown that sustained ERK activation induced by nerve growth factor (NGF) led to neuronal differentiation while transient ERK activation following EGF treatment elicited a non differentiating proliferative response [XREF_BIBR]."
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"Taken together, these studies show that differentiation of NT2 cells by RA or AraC is accompanied by an initial increase in PLCβ1 levels similar to that observed in NGF-induced differentiation of PC12 cells [35] and suggest that this phenomenon is general to neuronal differentiation and independent of progenitor type.PLCβ4 isoform has been reported to be up-regulated during RA-induced neuronal differentiation of NT2 cells [43]."
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"It has also been shown that NGF and NGF receptors are expressed by cells of the posterior segment, including vitreous and choroid [83, 92], and topical NGF administration has been shown to modulate the development and differentiation of the retina and the optic nerve, and to promote the survival and recovery of retinal ganglion cells (RGCs) [10, 93].4.1
Corneal Ulcers."
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"The most probable cause of reduced miRNA activity could be the unbinding of miRNA with Ago2 proteins, which is known to happen in the mammalian macrophage during its activation phase and also in neuronal cells during the nerve growth factor-induced differentiation process.19 26 To check whether similar effects on Ago2 by Aβ may cause the downregulation of miRNA-Ago2 binding in Aβ -treated astrocytes, we cultured primary astrocytes from rat pups and treated them with DMSO or Aβ for 24 h. Ago2 was immunoprecipitated (IP) followed by qPCR-based measurement of bound miRNAs."
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"To study whether RICH proteins participate in the extension of neurites or the formation of new branches in neurons, stable transfectants of the pro neuronal PC12 cell line were generated to express high levels of zRICH during the differentiation triggered by NGF treatment (XREF_FIG)."
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"To prove this hypothesis, we blocked the action of endogenous NGF using both a specific antibody anti-NGF and a specific TRKA antagonist, finding that sequestration of the secreted NGF in the culture medium or TRKA blocking impairs OPC differentiation/maturation, resulting in an increased percentage of undifferentiated precursors (OPCs, NG2-positive cells) and a dramatic decrease in the percentage of mature (CNPase-positive) and myelinating (MBP-positive) OLs."
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"Inorganic mercury has been shown to change the fate of murine central nervous system stem cells, alter neuronal differentiation, affect neurotransmitter production, alter the conductance of L-type calcium channels, potentiate calcium signals elicited by depolarization or agonist stimulation, enhance NGF induced differentiation in PC-12 cells, and modify calcium signals, thereby activating apoptosis in cell lines [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Consistent with their potency in inducing neurite outgrowth when stimulated with EGF, BPGAP1-BCH, BPGAP1, and BPGAP1-R232A also potentiated a similarly potent neurite outgrowth upon stimulation with a suboptimal level of NGF (10 ng/ml), which by itself did not induce PC12 differentiation (XREF_FIG and XREF_FIG)."
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"XREF_BIBR We assessed Syn ability in modulating MT assembly in such neuronal compartment using differentiated rat PC12 cells, which naturally express rat Syn starting from 7th day of NGF treatment; XREF_BIBR therefore, we transfected human WT or human mutant Syn and we performed experiments at 5th day of NGF induced differentiation."
| PMC
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"Consequently, the aim of this study was to determine whether the rat pheochromocytoma derived PC12 cell line expresses the prodynorphin gene, if it secretes dynorphins, and if the NGF induced differentiation of PC12 cells toward sympathetic neurons affects the secretion of the latter."
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"In conclusion, it appears that while changes in the secretion of proenkephalin derived peptides may serve as a marker of PC12 cell differentiation toward chromaffin cells, an increase in the secretion of prodynorphin derived peptides may represent a marker of NGF induced differentiation of PC12 cells toward sympathetic neurons."
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"For neuronal differentiation, PC12 cells were treated with 50 ng/ml NGF in a low-serum medium (DMEM supplemented with 2% FBS, 1% penicillin and streptomycin, and 1% L-glutamine) every 24 h for 96 h. Every 48 h, culture media was removed and replaced with fresh media and NGF according to Binnington and Kalisch."
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"Also, in PC12 cells, differentiation is triggered by the addition of NGF to the culture media, allowing examination of effects at specific stages of neurodevelopment, beginning at cell replication and extending though differentiation; these types of determinations require coordinated and uniform differentiation of the cell population, a situation that can not be modeled in vivo."
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"In addition to the canonical NGF-TrkA-PI3K-Akt signaling axis, essential for axonal growth and neuronal survival (Chao 2003; Alberghina and Colangelo, 2006), NGF induces cell differentiation through: i) G protein induced microtubule rearrangement, ii) release of cyclic adenosine monophosphate (AMP), and iii) expression of shootin-1, a potential mediator of axon formation and neuron polarization (Ng et al., 2009; Sierra-Fonseca et al., 2014; Ergin et al., 2015)."
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"NGF-induced differentiation results in altered ATP and NADPH contents, higher respiration, increased glucose metabolism, higher glucose transport rates, higher activities of hexokinase and of the pentose phosphate pathway, which is involved in the production of fatty acids and neurotransmitters required for the growth of neurites (Waki et al., et al., 2001; Martorana et al., 2018 and references therein)."
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"Because they are responsive to a wide range of different extracellular stimuli PC12 cells have been widely used as a model for examining how neurotransmitters and neurotrophic factors activate IEG transcription.Treatment of PC12 cells with growth factors such as epidermal growth factor (EGF) which is a mitogen for these cells, or NGF which induces neuronal differentiation, leads to IEG activation within minutes (Greenberg et al, 1985; Kruijer et al, 1985; Milbrandt, 1988)."
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"In this study, we established an NGF induced PC12 differentiation model to screen novel compounds that have the potential to induce neuronal differentiation, and further characterized 4,10-Aromadendranediol (ARDD) isolated from the dried twigs of the Baccharis gaudichaudiana plant, which exhibited the capability of promoting neurite outgrowth in neuronal cells in vitro."
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"Together, NGF presence induced an increase in the number of synapses in AMCCs to promote neuronal differentiation, while K252a inhibits this reaction.PNMT is an enzyme biosynthesized by the adrenal medulla, which catalyzes the biosynthesis of catecholamines and methylates NE to form EPI (43)."
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"Since all PC12 subclones expressing detectable levels of the dominant inhibitory Ras protein are resistant to NGF induction of neurite formation, our observations support the notion that sustained activation and translocation of ERKs into the nucleus are essential for NGF induced neuronal differentiation of PC12 cells."
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"30 The ovaries of these animals (analyzed on postnatal day 7) not only have more oocytes that fail to be encapsulated by somatic cells into a follicular structure, but also exhibit a reduced number of primary and secondary follicles, indicating that NGF supports the sequential processes of granulosa cell differentiation and proliferation underlying the conversion of primordial into secondary follicles."
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"In brief, RSC96 cells were first seeded on different scaffolds and cultured for 3 days, followed by PC12 cells seeded on them and cultured for another 7 days, and NGF and GDNF were added to the culture medium during the culture period to promote differentiation and maturation of the co-culture system."
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"These results (1) indicate that the diversity of Ca2+ currents in PC12 cells arise from the expression of three distinct alpha1 and three different beta subunit genes; (2) support a model for heterogenous beta subunit association of the N-type Ca2+ channel in a single cell type; and (3) suggest that the regulation of the N-type Ca2+ channel during NGF mediated differentiation involves an increase in the number of functional channels with no apparent changes in subunit composition."
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"Although the degree of morphological differentiation did not increase in proportion to the TrkA expression induced by IFN-gamma, continuous loading of both IFN-gamma and NGF caused marked morphological differentiation in a cultured KP-N-RT cell line and SK-rib cells during 10 days."
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"The usefulness of this response map analysis is particularly apparent when comparing an EGF stimulus, which primarily promotes proliferation and has an activation vector with higher relative pAKT, to the NGF stimulus, which promotes mostly differentiation and has a vector with higher relative pERK (XREF_FIG)."
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"First described by Levi-Montalcini and Hamburger in 1953, nerve growth factor (NGF), a member of a family of growth and survival factors known as neurotrophins, promotes the neural differentiation and survival of basal forebrain cholinergic neurons and peripheral sensory neurons [XREF_BIBR, XREF_BIBR]."
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"Secreted NGF can also drive the growth and differentiation of both B- and T-lymphocytes [69,70] in a pattern consistent with the elevated expression of these cell populations in the LDP samples.A limitation of the current study is the absence of PCR confirmation of identified targets as performed in some prior studies [5,15,22]."
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"A well documented example for signal specificity determination is found in rat phaeochromocytoma PC12 cells where epidermal growth factor (EGF) stimulation produces a transient mitogen activated protein kinase (MAPK) activation and leads to cell proliferation while nerve growth factor (NGF) initiates a sustained MAPK activation and induces cell differentiation."
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"The hypothesis of Mulhall that early penile size reduction is the result of sympathetic hyperinnervation is based on the fact that nerve growth factor (NGF), a neurotrophin which is released after peripheral nerve damage, induces differentiation of sympathetic neurons and enhances target innervation [XREF_BIBR, XREF_BIBR]."
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"It is possible that the dramatic morphologic changes observed during NGF induced differentiation of PC12 cells are associated not only with increased synthesis in the Golgi apparatus of plasma membrane components such as gangliosides, but also with increased degradation in lysosomes of other plasma membrane components such as sulfatide."
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"Previous studies have suggested that the ERK and MAPK pathway is crucial for NGF induced neuronal differentiation of cells because blocking ERK and MAPK activation inhibits neurite induction, and constitutive activation of the ERK and MAPK pathway results in neurite outgrowth XREF_BIBR."
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"PC12 cells exhibit precise temporal control of growth factor signaling in which stimulation with epidermal growth factor (EGF) leads to transient extracellular signal regulated kinase (ERK) activity and cell proliferation, whereas nerve growth factor (NGF) stimulation leads to sustained ERK activity and differentiation."
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"On the other hand, considering the results of the in vitro assay showing that DDAH1 could force NSCs to differentiate into ChAT neurons, we speculated that ChAT neurons differentiated by DDAH1 in turn induce the proliferation of surrounding NSCs.The PC12 cell line is a simple and stable model for observing neural differentiation induced by NGF."
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"Indeed, current studies indicate that NGF stimulates growth and differentiation of stem cell in EAE, exerts anti-inflammatory action and reduces the severity of EAE in non human primate, prospecting the clinical potentiality of NGF for MS. However, despite these findings, crucial evidences, such as, the identification and characterisation of the mechanism (s) implicated in tissue repair and in inflammatory responses, needs to be done to evaluate the role of NGF to identify potential therapeutic strategies for this demyelinating disorder."
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"The discovery of the ability of positive allosteric modulators of the AMPA receptor to induce the expression of neurotrophic factors BDNF and NGF, triggering the mechanisms responsible for the survival of existing functioning neurons, as well as growth and differentiation, the formation of new synapses makes the development of new drugs based on tricyclic derivatives of 3,7-diazabicyclo [3.3.1] nonane is especially promising for use in the later stages of post-stroke rehabilitation."
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"Nerve growth factor (NGF) induced differentiation of PC12 cells, and after 12 days of NGF treatment there were large increases in the levels of the heterotrimeric G protein subunits alpha o1, alpha i1, beta, and alpha s, small increases in those of alpha i2 and alpha q, and a slight decrease in that of alpha o2."
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"The illumination of NGF’s critical role in neuronal development eventually led to the creation of the “neurotrophic factor hypothesis” and the classical neurotrophic model in which NGF is synthesized and released by target tissues during embryonic development, promoting the growth, differentiation, and survival of neurons in a dose-dependent manner."
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"To test the hypothesis that dual and sustained delivery of GDNF and NGF with different release kinetics can modulate neural differentiation, the morphology of PC12 cells cultured on different scaffolds was investigated and neurite length was measured for determining neural differentiation percentages."
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"The frequency of upstream stimuli may thus be decoded into distinct cellular responses, consistent with recent studies showing that pulsatile NGF stimulation induces more homogenous differentiation in PC-12 cells than does continuous stimulation, as well as by the finding that certain frequencies of osmolarity stress dramatically reduce yeast cell growth."
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"Although the growth factor effects predominated (e.g., EGF induced maintenance of NSCs and NGF induced neural differentiation), the ECM also played a role, as illustrated by much less extensive NT-3-induced neural and CNTF induced astroglial differentiation on laminin vs. fibronectin [XREF_BIBR]."
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"Notably, in the same work confocal time-lapse analysis during NGF induced differentiation made it possible to detect real-time transport of vesicles carrying activated full-length TrkA in anterograde and retrograde directions and to measure a transport velocity of ~ 0.5 microm/s in both cases."
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"NGF caused a significant stimulation of granulocyte differentiation from human peripheral blood and murine bone marrow cells, suppressed apoptosis of rodent neutrophils and peritoneal mast cells, enhanced functional properties of murine neutrophils and human eosinophils, and not only promoted colony formation of murine IL-3-dependent bone marrow derived cultured mast cells, but also induced the phenotypic change to connective tissue-type mast cells."
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"GP-17 exerted protective effect against Aβ -induced neurotoxicity in nerve growth factor-induced differentiation of PC12 cells, including oxidative stress, apoptosis, and autophagic cell death, which might be related to estrogen receptor-dependent activation of PI3K/Akt pathways, inactivation of GSK-3β, and activation of nuclear factor-erythroid 2-related factor 2/antioxidant responsive element/heme oxygenase 1 (Nrf2/ARE/HO-1) pathways [83]."
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"This was not accompanied by any changes in the expression of Apaf-1, suggesting that inhibition of caspase-9 activation was not due to down-regulation of Apaf-1 which has been reported to occur during NGF mediated differentiation of sympathetic neurons over 7 days [XREF_BIBR], but instead upstream of apoptosome formation."