IndraLab

Statements

PSMD14 activates SMAD3. 5 / 5
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"In this study, POH1 was identified as a DUB of Smad3, increasing its stability and activating Smad3 downstream targets."
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"Furthermore, we revealed the mechanism by which increased POH1 expression contributes to the development of NSCLC by stabilizing Smad3."
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"N-cadherin, E-cadherin, and vimentin are markers of EMT [ 46 ], indicating that POH1 promotes EMT in lung cancer cells by mediating the stability of Smad3."
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"Consistently, our findings demonstrate that POH1 promotes cell proliferation, invasion, and metastasis in NSCLS by mediating Smad3 stability."
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"Overexpression of POH1 in H1299 cells significantly prolonged the half-life of the endogenous Smad3 protein ( Fig. 2 A)."
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