IndraLab

Statements

TP53 binds USP22. 4 / 4
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"In addition, the identified USP22-p53 interaction is of potential biological significance."
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"USP22 appears to form a complex with Sirt1 and p53 to suppress p53 acetylation, since we detected the interaction of USP22 with p53 in transiently transfected HEK293 cells ( Figure 5 E)."
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"However, the interaction of USP22 with p53 was only detected in wild-type but not in sirt1 null MEF cells ( Figure 5 F)."
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"Therefore, the interaction of USP22 with p53 is probably mediated by Sirt1."
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