IndraLab

Statements


EGFR phosphorylates RAF1 on tyrosine. 3 / 3
| 3

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"beta-AR-initiated cAMP signaling may transactivate the epidermal growth factor receptor (EGFR) pathway, including overexpression of EGFR specific phosphorylated tyrosine kinase, Raf-1, and extracellular signal regulated kinase 1/2 (ERK1/2) and ERK1/2 phosphorylation (XREF_FIG)."

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"In lung adenocarcinoma of hamsters, the overexpression of PKA, cAMP, CREB and phosphorylated CREB in beta2-adrenergic receptor pathway and EGFR specific phosphorylated tyrosine kinase, Raf-1 and ERK1/2 and their phosphorylated forms in EGFR pathway were observed [XREF_BIBR]."

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"Our immunohistochemical analysis of NNK induced PAC in hamsters demonstrates the simultaneous over-expression of a beta2-adrenergic receptor pathway, including PKA, cAMP, CREB and phosphorylated CREB and of an EGFR pathway, including over-expression of EGFR specific phosphorylated tyrosine kinase, Raf-1 and ERK1/2 and their phosphorylated forms."