IndraLab

Statements

RNAi inhibits KCNH3. 3 / 3
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reach
"Interestingly, we found that RNAi mediated inhibition of bec-1, lgg-1, vps-34, or the putative autophagy inducer pha-4 all significantly reduced the lifespan of LIPL-4 overexpressing animals, while having negligible effects on non transgenic siblings (XREF_FIG, and XREF_SUPPLEMENTARY)."
21906946
reach
"Using transgenic Caenorhabditis elegans expressing fluorescent UPS reporters, we show that the downregulation of the autophagy genes lgg-1 and lgg-2 (ATG8/LC3/GABARAP), bec-1 (BECLIN1), atg-7 (ATG7) and epg-5 (mEPG5) by RNAi decreases proteasomal degradation, concomitant with the accumulation of polyubiquitinated proteasomal substrates in a tissue specific manner."
32784405
reach
"In double mutants of rab-7 with sorf-1 or sorf-2, RNAi depletion of vps-34, bec-1, or Y34B4a.2, which encodes the C. elegans homolog of UVRAG, strongly suppressed the enlargement of early endosomes in hypodermal cells (XREF_FIG)."
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