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R)-3-amino-3-phenylpropan-1-ol at C-4 activates KCNH2. 1 / 1

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"However, some of the privileged structures in terms of potency had ADME short-comings : compounds containing amides, sulfonamides, amine and hydroxymethyl substituents in the 6-aryl group had low permeability and high efflux, derivatives having (R)-3-amino-3-phenylpropan-1-ol at C-4 induced hERG inhibition properties, and metabolic lability was seen for compounds having (S)-2-methoxy-1-phenylethan-1-amine at C-4."

27614407

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IndraLab

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R)-3-amino-3-phenylpropan-1-ol at C-4 activates KCNH2. 1 / 1

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