IndraLab

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MiR-126 decreases the amount of IRS1. 3 / 3
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"The knockdown of miR-126 promotes AKT and ERK1/2 activation by upregulating the expression of IRS-1, a target gene of miR-126 [XREF_BIBR]."
26307974
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"To confirm that IRS-1 is a target gene of miR-126 in hepatocytes, we transfected SK-Hep1 cells with empty plasmid or miR-126 expression plasmid, and investigated whether induction of miR-126 directly represses IRS-1 expression."
21464990
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"Our findings in hepatocytes reveal a novel mechanism for the development of insulin resistance by providing the first direct evidence that miR-126 mediates the repression of IRS-1 expression in mitochondrial dysfunction."
21464990