IndraLab

Statements

Copper(2+) inhibits KCNMA1. 5 / 5
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"Instead, Cu 2+ inhibits BK channel activation, shifting the half activation voltage (V 0.5) of the G K -V relation to more positive voltages by +82 mV and decreasing G Kmax by ~ 18% in 1000 muM Cu 2+ as estimated by fits to Boltzmann functions (XREF_FIG)."
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"Macroscopic BK channel potassium current (I K) evoked by membrane depolarization is reduced markedly and rapidly by 100 muM extracellular Cu 2+ (XREF_FIG)."
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"If Cu 2+ inhibits BK channel activation by binding in a state dependent manner to the voltage sensor, then mutations in the binding site may alter not only IC 50 but also efficacy."
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"The physiological importance of BK channel inhibition by Cu 2+ is unknown."
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"Extracellular Cu 2+ Inhibits BK Channel Activation."
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