IndraLab

Statements

USP5 inhibits Ubiquitin. 7 / 7
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"Isopeptidase T specifically degrades unanchored polyubiquitin chains by removing individual ubiquitin subunits in a step-wise fashion from the proximal end of the chain (Hadari et al., 1992)."
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"Thus, Leon and USP5 holds Ubqn in check and prevents ubiquitin homeostatic imbalance, making USP5 as a potential candidate disease gene in ubiquitin homeostasis related diseases."
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"Intriguingly, inhibition of ubiquitin by isopeptidase inhibitor (G5), which causes depletion of free nuclear ubiquitin [ xref ], prevented Top 1 degradation in CPT-treated T cells (4)."
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"We observed that both LRSAM1 and HRD1 displayed apparent autoubiquitination, and much of this signal was resistant to IsoT treatment, which degrades unanchored ubiquitin chains."
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"In a cell study, USP5 and USP13 were found to degrade ubiquitin chains inside stress granules, defined as clumps of protein or RNA created when cells are stressed [XREF_BIBR]."
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"Interestingly, although the RIG-I complex isolated from HEK293T cells contains both IsoT sensitive unanchored ubiquitin chains and IsoT resistant ubiquitin conjugates, the IsoT treatment completely abolished the ability of these ubiquitin chains to activate RIG-I (XREF_FIG), strongly suggesting that unanchored polyUb chains are responsible for RIG-I activation."
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"IsoT also reduced the pro-IL-1beta-associated ubiquitin (XREF_FIG, 4 th lane)."
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