IndraLab

Statements

RPL5 binds RPL11, MDM2, and TP53. 4 / 4
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sparser
"Under conditions of defective ribosome biogenesis, this apoptotic response is triggered by the ‘nucleolar stress response’, the binding of excess ribosomal proteins, such as RPL5 and RPL11, to Mdm2, which in turn prevents Mdm2 mediated p53 degradation [ xref ]."
25756904
reach
"RPL4 interacts with the RPL5, RPL11, MDM2, and p53 complex in cells."
26908445
reach
"These results suggest that RPL4 may associate with the RPL5, RPL11, MDM2, and p53 complex."
26908445
sparser
"Two ribosome proteins, RPL5 and RPL11 are major mediators of this Ribi checkpoint; excess RPL5 and RPL11 bind Mdm2 and inhibit its interaction with p53, causing p53 to accumulate ( xref )."
26165925