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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CA1 decreases the amount of HCN1. 2 / 2

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"Despite the fact that HCN1 protein levels are reduced by 40% in area CA1 XREF_BIBR we find that HCN1 expression in the dentate gyrus is increased in adult TRIP8b -/- compared to wildtype mice (XREF_FIG; arrows in 1e)."

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"Molecular analysis demonstrated the colocalization of HCN1 and HCN2 with PRMT7 in the CA1 region in the WT mice, and PRMT7 deficiency in CA1 causes reduced HCN1 protein levels without alteration in the HCN2 protein levels or reduction in the HCN1 mRNA levels."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...